N-Boc-4-oxo-L-proline methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 256487-77-1 |
| Product name | N-Boc-4-oxo-L-proline methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Boc-4-oxo-L-proline methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Boc-4-oxo-L-proline methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Boc-4-oxo-L-proline methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Organic synthesis intermediate | Used in the synthesis of peptides and drug molecules; serves as a protected amino acid derivative in coupling reactions |
| Chemical research | Chiral synthesis building block | Applied as a chiral template or precursor in asymmetric synthesis to construct complex molecular architectures |
| Pharmaceutical manufacturing | Prodrug development | Involved in structural modification of active pharmaceutical ingredients (APIs) to enhance selectivity and stability |
Manufacturing Quality Control of N-Boc-4-oxo-L-proline methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210–220 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment via separation on a chiral stationary phase (e.g., Chiralpak AD-H or OD-H), with UV detection. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., methanol, THF, DCM) using headspace gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration based on the reaction of iodine with water in anhydrous pyridine/methanol medium, providing precise moisture quantification. |
| Heavy Metals | ICP-MS | Multi-element trace metal analysis (e.g., Pb, Cd, Hg, Ni) after acid digestion, utilizing inductively coupled plasma mass spectrometry for sub-pptr detection. |
| Residual Palladium | ICP-OES | Quantification of palladium catalyst residues post-hydrogenation, following microwave-assisted acid digestion and plasma optical emission detection. |
| Related Substances | HPLC-UV (Forced Degradation Study) | Detection and quantification of structurally related impurities (e.g., de-Boc, hydrolyzed ester, diketopiperazine) under stressed conditions (acid/base/oxidative/thermal). |
| Optical Rotation | [α]D Measurement | Determination of specific rotation using a digital polarimeter at 20 °C with sodium D-line (589 nm), confirming stereochemical integrity per USP/EP monograph requirements. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition analysis by controlled heating of crystalline sample; used for identity confirmation and purity screening (sharp melting range indicates high purity). |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder morphology using Mie theory-based light scattering to ensure consistent bulk handling and downstream processing performance. |
| Residual Chloride | Ion Chromatography (IC) | Quantification of chloride ion from incomplete quenching or HCl salt formation, using suppressed conductivity detection after anion exchange separation. |
| Microbial Contamination | Membrane Filtration + TSA/TSA+SCDA | Aerobic microbial enumeration per Ph. Eur. 2.6.12, using membrane filtration followed by incubation on Tryptic Soy Agar (TSA) and Sabouraud Dextrose Agar (SDA). |
Technical Specifications of N-Boc-4-oxo-L-proline methyl ester
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +21.0 to +25.0° (c=1, in CHCl3) |
| Melting Point | 78 to 82°C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Boc-4-oxo-L-proline methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Boc-4-oxo-L-proline methyl ester
Safety Information of N-Boc-4-oxo-L-proline methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-Boc-4-oxo-L-proline methyl ester
Industrial N-Boc-4-oxo-L-proline methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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