1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide, 1-[(2-fluorophenyl)methyl]-, hydrochloride (1:1) Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 256499-19-1 |
| Product name | 1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide, 1-[(2-fluorophenyl)methyl]-, hydrochloride (1:1) |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 256499-19-1
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 256499-19-1 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 256499-19-1
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as an intermediate in the synthesis of JAK kinase inhibitors (e.g., tofacitinib) | Multi-step organic synthesis involving condensation, cyclization, and salt formation |
| Pharmaceutical Manufacturing | Used to prepare active pharmaceutical ingredients (APIs) for anti-inflammatory and immunomodulatory drugs | Catalytic hydrogenation, nucleophilic substitution, and hydrochloride salt crystallization for purification |
| Biochemical Research | Used as a lead compound or probe molecule in kinase target studies | High-throughput screening coupled with structure-based synthetic route optimization |
Manufacturing Quality Control of 256499-19-1
| Test Item | Commonly Used Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, physical state, presence of caking, and visible foreign matter under natural or standard lighting conditions. |
| Identification | Infrared Spectroscopy (IR) | Compare the sample spectrum with the reference spectrum to confirm consistency of characteristic functional group absorption peaks (e.g., N-H, C=N, C-F, etc.). |
| Nuclear Magnetic Resonance Spectroscopy (¹H-NMR, ¹⁹F-NMR) | Analyze the chemical shifts and coupling constants of hydrogen and fluorine atoms in the molecular structure to verify structural correctness. | |
| Mass Spectrometry (MS or HRMS) | Determine molecular ion peaks ([M+H]+ or [M]⁺), confirm molecular weight and fragment ions to verify the compound's structure. | |
| Purity/Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column and UV detector (typically at 254 nm or selected based on maximum absorption wavelength). Calculate the purity of the main peak using external standard method or area normalization method. |
| Water Content | Karl Fischer Titration | Suitable for determining trace amounts of water in solid samples, using either volumetric or coulometric methods to accurately measure both free and bound water. |
| Residual Solvents | Gas Chromatography (GC) | Detect organic solvents possibly residual from the manufacturing process (e.g., methanol, ethanol, dichloromethane, DMF, etc.) in accordance with ICH Q3C guidelines, using appropriate detectors (FID). |
| Related Substances (Impurities) | HPLC with Gradient Elution | Detect process impurities and degradation products. Evaluate individual impurity peaks using reference standards or relative response factors to ensure total impurities meet specified limits. |
| Melting Point | Capillary Melting Point Method | Determine the temperature range at which the compound transitions from solid to liquid using a melting point apparatus, used for preliminary assessment of purity and material characteristics. |
| Solution Clarity and Color | Visual Color Comparison | Prepare a solution of specified concentration and compare its clarity and color with standard color solutions to assess whether it is clear and colorless or within acceptable limits. |
| Chlorides (for Hydrochloride salts) | Ion Chromatography or Argentometric Method | Quantitatively determine chloride ion content in hydrochloride salts to verify the salt formation ratio and control inorganic impurities. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Thioacetamide Method | Detect residual toxic elements such as lead, cadmium, mercury, and arsenic, ensuring compliance with pharmacopoeia or ICH Q3D elemental impurity limits. |
| Sulfated Ash (Residue on Ignition) | Gravimetric Analysis | Weigh the residue after high-temperature ignition of the sample to assess the content of inorganic impurities. |
| Microbial Limits | Microbial Limit Testing | Perform tests for total aerobic microbial count, total combined molds and yeasts count, and specified microorganisms (e.g., Escherichia coli) as per pharmacopoeia requirements. Applicable for non-sterile active pharmaceutical ingredients. |
Technical Specifications of 256499-19-1
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 195–199 °C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 256499-19-1
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
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Industrial 256499-19-1 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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