TERT-BUTYL 7-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 258515-65-0 |
| Product name | TERT-BUTYL 7-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 258515-65-0
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 258515-65-0 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 258515-65-0
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for synthesizing dopamine D1 receptor agonist candidates (e.g., PF-06412562) | Used as a key building block in coupling reactions to introduce aryl or heteroaryl substituents via palladium-catalyzed cross-coupling, followed by deprotection and structural modification |
| Pharmaceutical R&D | Construction of protein kinase inhibitors containing an isoquinoline scaffold | Functionalization at the C1 position via lithiation–electrophilic trapping, followed by cyclization or further derivatization to construct the target molecule’s core structure |
| Organic Synthesis | Chiral precursor for asymmetric synthesis of isoquinoline derivatives | Preparation of optically active isoquinoline derivatives via asymmetric alkylation/arylation reactions controlled by chiral auxiliaries or chiral catalysts |
Manufacturing Quality Control of 258515-65-0
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 220-254 nm, comparing peak area to reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., starting materials, dehalogenated or hydrolyzed by-products) using gradient HPLC-UV. |
| Residual Solvents | GC-FID | Measures residual solvents (e.g., THF, DMF, toluene) by gas chromatography with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration | Determines trace water content via coulometric or volumetric titration using iodine generation in pyridine-free reagents. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pd, Ni, Fe) by inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction. |
| Residual Palladium | ICP-OES | Measures palladium residue from coupling catalysts by inductively coupled plasma optical emission spectroscopy post-digestion. |
| Optical Rotation | [alpha]D Measurement | Determines specific optical rotation using a polarimeter at 20 C and 589 nm to confirm chiral integrity. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Appearance | Visual Inspection | Assesses physical state, color, and homogeneity of crystalline solid against defined reference standards under controlled lighting. |
| Loss on Drying | Gravimetric Analysis | Determines volatile content by measuring weight loss after drying at 60 C under vacuum for 2 hours. |
| Residual Tert-Butyl Alcohol | GC-FID | Quantifies residual tert-butyl alcohol (from Boc group cleavage) by headspace GC-FID using external calibration. |
Technical Specifications of 258515-65-0
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 112–116°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 258515-65-0
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 258515-65-0
Packaging of 258515-65-0
Industrial 258515-65-0 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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