China Factory Direct
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| CAS number | 25981-83-3 |
| Product name | 5-Chloro-2,3,3-trimethyl-3H-indole |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthetic intermediate for preparing bioactive indole derivatives, including anticancer and anti-inflammatory drug candidates | Functional groups introduced via nucleophilic substitution, alkylation, or coupling reactions to construct complex molecular frameworks |
| Dyes and Photosensitive Materials | Synthesis of cyanine dyes and near-infrared fluorescent probes | Condensation with heterocyclic compounds containing reactive halogen atoms to form conjugated chromophore structures |
| Organic Synthesis | Building block for synthesizing indole derivatives with tailored optoelectronic properties | Participates in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) or classical indole functionalization reactions such as Vilsmeier–Haack formylation |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 254 nm, based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally similar impurities using gradient HPLC-UV; identification by retention time matching and/or spiked reference standards. |
| Residual Solvents | GC-FID | Separates and quantifies volatile organic solvents (e.g., toluene, methanol) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generation in pyridine/methanol-based reagent. |
| Heavy Metals | ICP-OES | Measures total elemental metal content (e.g., Pb, Cd, Ni, Fe) after acid digestion, using inductively coupled plasma optical emission spectroscopy. |
| Chloride Ion Impurity | Ion Chromatography | Separates and quantifies chloride anions using suppressed conductivity detection after aqueous extraction. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of foreign particles under controlled white light against defined reference standards. |
| Loss on Drying | Gravimetric Method | Measures mass loss after drying at specified temperature (e.g., 105 C) for fixed duration, indicating volatile content. |
| Specific Optical Rotation | Polarimetry | Measures rotation of plane-polarized light by chiral molecules in solution using sodium D-line (589 nm) light source. |
| Residue on Ignition | Gravimetric Ash Test | Quantifies inorganic residue remaining after high-temperature incineration (700–800 C) of sample in platinum crucible. |
| pH of Aqueous Suspension | pH Meter | Measures hydrogen ion activity in a standardized suspension (e.g., 1% w/v in water) using calibrated pH electrode. |
| Test Item | Specification |
|---|---|
| Appearance | Red solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 124–128°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.