D-3-Cyanophenylalanine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 263396-43-6 |
| Product name | D-3-Cyanophenylalanine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for D-3-Cyanophenylalanine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk D-3-Cyanophenylalanine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of D-3-Cyanophenylalanine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral drug intermediate for synthesizing the key chiral side chain of the antiplatelet agent ticagrelor | Preparation of the ticagrelor active enantiomer via chiral resolution or asymmetric synthesis, followed by amide coupling, cyclization, and other steps to introduce the pyrimidinyltriazole core |
| Pharmaceuticals | Structural modification unit for novel protease inhibitors and peptide-based drugs | Used as a non-natural amino acid in solid-phase peptide synthesis (SPPS) to construct peptide sequences with enhanced metabolic stability and target selectivity |
| Fine Chemicals | Synthetic precursor for chiral ligands and catalysts | Coordination with transition metals (e.g., Pd, Ru) to form chiral phosphine–amino acid hybrid ligands for asymmetric C–C bond coupling reactions |
Manufacturing Quality Control of D-3-Cyanophenylalanine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-220 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A/B. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common solvents (e.g., methanol, acetone, DMF) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water via stoichiometric reaction with SO2 and base in methanol medium. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation using a polarimeter at 20 °C with sodium D-line (589 nm) to confirm chiral integrity and enantiomeric purity. |
| Heavy Metals | ICP-MS | Quantitative multi-element analysis after acid digestion; detection of Pb, Cd, Hg, As, and others at sub-ppb levels using mass spectrometry. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column with suppressed conductivity detection. |
| Sulfated Ash | Gravimetric Analysis | Ignition of sample at 600-700 °C followed by weighing of non-volatile inorganic residue after sulfuric acid treatment. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating crystallinity and absence of significant impurities. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using light scattering to obtain volume-based particle size distribution (D10, D50, D90). |
| Bulk Density | Tap Density Tester | Measurement of mass per unit volume after controlled tapping to assess powder flow and handling characteristics. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per Ph. Eur. 2.6.12. |
Technical Specifications of D-3-Cyanophenylalanine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 178-182°C |
| Optical Rotation | +11.0 to +14.0 (c=1, in 1M HCl) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of D-3-Cyanophenylalanine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of D-3-Cyanophenylalanine
Packaging of D-3-Cyanophenylalanine
Industrial D-3-Cyanophenylalanine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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