Calcium N5-methyltetrahydrofolate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 26560-38-3 |
| Product name | Calcium N5-methyltetrahydrofolate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeFood Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Calcium N5-methyltetrahydrofolate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Calcium N5-methyltetrahydrofolate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Calcium N5-methyltetrahydrofolate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Treatment of folate deficiency, megaloblastic anemia, and hyperhomocysteinemia; antidote for methotrexate toxicity | Active pharmaceutical ingredient in oral or injectable formulations; participates in one-carbon unit transfer reactions to support DNA/RNA synthesis and repair |
| Nutritional Supplements | Bioactive form of folate in dietary supplements for maternal nutrition support and neural tube defect prevention | Incorporated into multivitamin and prenatal nutritional supplements to enhance bioavailability and metabolic efficiency |
| Food Fortification | Fortification of staple foods such as flour and cereals to prevent population-level folate deficiency | Uniformly blended into food matrices via dry or wet mixing processes using calcium L-methylfolate |
| Biotechnology | Supplement in cell culture media to support mammalian cell growth and proliferation | Provides a reduced folate source in serum-free or chemically defined media |
Manufacturing Quality Control of Calcium N5-methyltetrahydrofolate
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | Utilizes a reversed-phase C18 column with UV or diode array detection (DAD), employing mobile phases such as phosphate buffer-methanol for quantification via the external standard method. Offers high specificity and accuracy, suitable for quantitative analysis of active ingredients in both active pharmaceutical ingredients (APIs) and formulations. |
| Purity and Related Substances | High-Performance Liquid Chromatography (HPLC) | Optimizes gradient elution procedures based on assay methods to separate and detect potential degradation products, isomers, or other impurities. Total impurity content is calculated using peak area normalization or external standard calibration against reference standards, ensuring compliance with pharmacopoeial purity requirements. |
| Water Content | Karl Fischer Titration | Determines moisture content in samples using Karl Fischer reagent, available in volumetric or coulometric modes. Suitable for detecting residual moisture in APIs to control critical stability parameters. Simple to operate with high sensitivity. |
| Residual Solvents | Gas Chromatography (GC) | According to ICH guidelines, detects organic solvents used during manufacturing (e.g., methanol, ethanol, acetone). Typically employs headspace sampling with a flame ionization detector (FID) to ensure solvent residues remain within safe limits. |
| Polymorph Analysis | X-ray Powder Diffraction (XRD) | Analyzes crystalline structure characteristics to confirm polymorphic consistency, preventing variations in solubility and stability due to different polymorphic forms. Used for evaluating batch-to-batch consistency of APIs. |
| Infrared Identification | Fourier Transform Infrared Spectroscopy (FTIR) | Compares sample spectra with reference standards by identifying characteristic absorption peaks (e.g., N-H, C=O, aromatic rings) to verify molecular structure and authenticate API identity. |
| Specific Rotation | Polarimetry | Measures the angle of optical rotation of a sample at a specific wavelength (e.g., sodium D line) to assess optical purity, particularly applicable to chiral compounds in quality control. |
| Solution Clarity and Color | UV-Visible Spectrophotometry / Visual Color Comparison | Observes solution clarity and absence of abnormal color after dissolution. Can be supplemented by UV-Vis spectrophotometry at specific wavelengths to quantify insoluble particles or colored impurities. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Thioacetamide Method (Pharmacopoeial Method) | ICP-MS provides high sensitivity and enables simultaneous detection of multiple heavy metals (e.g., lead, arsenic, cadmium, mercury); the traditional method uses sulfide colorimetry. Used to control inorganic impurity limits. |
| Microbial Limits | Microbial Limit Test (Pharmacopoeial General Chapter) | Includes total aerobic microbial count, mold and yeast count, and tests for specified control organisms (e.g., Escherichia coli, Salmonella spp.) to ensure microbial safety of non-sterile APIs. |
Technical Specifications of Calcium N5-methyltetrahydrofolate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Optical Rotation | -15.0° to -19.0° (c=1, in 0.1N NaOH) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Calcium N5-methyltetrahydrofolate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of Calcium N5-methyltetrahydrofolate
Industrial Calcium N5-methyltetrahydrofolate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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