(S)-Timolol maleate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 26921-17-5 |
| Product name | (S)-Timolol maleate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-Timolol maleate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-Timolol maleate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-Timolol maleate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | β-adrenergic blocker for the treatment of glaucoma and ocular hypertension | Formulated as ophthalmic solutions to reduce intraocular pressure by inhibiting aqueous humor production |
| Pharmaceuticals | Adjunctive therapy for migraine (in certain countries/regions) | Administered orally or topically to modulate vascular tone and neural transmission |
| Pharmaceuticals | Research use: Chiral drug model compound | Used in pharmacokinetic, enantioselective metabolism, and receptor binding studies |
Manufacturing Quality Control of (S)-Timolol maleate
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Appearance | Visual inspection and physical measurement | Observe the sample as a white or off-white crystalline powder, and check physical properties such as solubility (easily soluble in water and methanol, slightly soluble in ethanol). |
| Identification | Infrared Spectroscopy (IR) | Compare with the reference spectrum; characteristic absorption peaks should match (e.g., amide I, II bands, carboxylic ester, benzene ring vibrations). |
| High-Performance Liquid Chromatography (HPLC) | Identify by comparing retention times with a reference standard. Chromatographic conditions: C18 column, mobile phase of buffer salt-acetonitrile gradient elution. | |
| Thin-Layer Chromatography (TLC) | Use silica gel plates, developing solvent system of chloroform-methanol-ammonia, and visualize spots under iodine vapor or UV light, comparing spot positions and Rf values. | |
| Related Substances (Impurity Profile) | High-Performance Liquid Chromatography (HPLC) | Gradient elution with detection wavelength of 220–280 nm. Limit: single impurity ≤0.1%, total impurities ≤0.5% (refer to pharmacopoeia limits). Quantify using main component self-dilution method or external standard method. |
| Assay | High-Performance Liquid Chromatography (HPLC) | Using (S)-Timolol Maleate reference standard, calculate content by external standard method. Requirement: 98.0%–102.0% (on anhydrous basis). Column: C18, mobile phase contains ion-pair reagent (e.g., sodium 1-heptanesulfonate) to improve peak shape. |
| Optical Rotation | Polarimetry | Prepare solution at specified concentration (e.g., 10 mg/mL), measure specific rotation at 20°C. (S)-isomer should be levorotatory, typical value: -25° to -30° (c=1, H₂O). |
| Water Content | Karl Fischer Titration | Determine by volumetric or coulometric method. Limit: ≤1.0%. Ensures product stability and prevents hydrolysis or moisture absorption. |
| Residual Solvents | Gas Chromatography (GC) | Test for residual solvents (e.g., methanol, ethanol, acetone, dichloromethane) according to ICH Q3C. Use headspace injection and FID detector. Quantitation limits must meet specifications. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After incineration, test for heavy metals such as lead, cadmium, and mercury. Limit: typically ≤10 ppm (according to pharmacopoeia general chapter). |
| Clarity and Color of Solution | Visible Spectrophotometry / Visual Color Comparison | Prepare solution and measure absorbance in visible range (e.g., 450 nm), or compare with standard color solutions. Ensure solution is clear and colorless. |
| pH Value | pH Meter | Prepare a 1% aqueous solution and measure at 25°C. Acceptable pH range: 4.0–6.0, to ensure formulation stability and biocompatibility. |
| Microbial Limits | Microbial Count and Control Organism Testing | Test for total aerobic microbial count, total combined molds and yeasts according to ChP General Chapter 1105/1106. Pathogens such as Escherichia coli must not be detected. |
| Particle Size Distribution (if used for formulations) | Laser Diffraction or Microscopy | Control particle size distribution to ensure dissolution and uniformity (e.g., D90 ≤50 μm), applicable for raw materials used in inhaled or suspension formulations. |
Technical Specifications of (S)-Timolol maleate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.5% (HPLC) |
| Optical Rotation | -5.6 to -5.2° (c=1, in water) |
| Melting Point | 148 to 152°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-Timolol maleate
| CAS/Product ID | *Required fields | |
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NMR Spectra of (S)-Timolol maleate
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Industrial (S)-Timolol maleate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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