4-Pyrazoleboronic acid pinacol ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 269410-08-4 |
| Product name | 4-Pyrazoleboronic acid pinacol ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Pyrazoleboronic acid pinacol ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Pyrazoleboronic acid pinacol ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Pyrazoleboronic acid pinacol ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) for constructing drug molecules containing a pyrazole ring. | Suzuki-Miyaura cross-coupling reaction |
| Organic synthesis | Used to construct biaryl or heterocyclic compounds; serves as an effective reagent for introducing the 4-pyrazolyl group. | Suzuki cross-coupling reaction |
| Agrochemicals | Applied in the synthesis of pyrazole-containing agrochemicals with herbicidal, insecticidal, or fungicidal activity. | Palladium-catalyzed cross-coupling reaction |
| Materials science | Used as a functional monomer or ligand in the synthesis of organic electronic materials or metal–organic frameworks (MOFs). | Cross-coupling reaction |
Manufacturing Quality Control of 4-Pyrazoleboronic acid pinacol ester
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity (HPLC) | High-Performance Liquid Chromatography (HPLC) | Uses a C18 reversed-phase column with acetonitrile/water or methanol/water as mobile phase, and a UV detector (typically 254 nm). Purity is assessed by peak area normalization or external standard method, suitable for quantitative analysis of purity and impurity levels. |
| Assay | HPLC External or Internal Standard Method | Accurately weigh the sample, prepare standard and test solutions. Establish a standard curve using a reference standard of known concentration to calculate the content of 4-pyrazoleboronic acid pinacol ester in the sample, meeting pharmacopoeia or company specifications (e.g., ≥98%). |
| Moisture Content | Karl Fischer Titration | Determines trace moisture in the sample by a quantitative reaction between water and an iodine-sulfur dioxide-pyridine-methanol system. Monitors moisture levels to prevent hydrolytic degradation, detected via potentiometric or endpoint indication. |
| Residual Solvents | Gas Chromatography (GC) | Headspace or direct injection GC-FID is used to detect residual solvents such as ethanol, methanol, ethyl acetate, and dichloromethane according to ICH Q3C guidelines. Separation is achieved using DB-624 or HP-INNOWAX columns, with quantitation via external standard method. |
| Melting Point | Melting Point Apparatus | Determine the melting temperature range using a digital melting point instrument (literature value ~85–89°C). Used for preliminary identification and batch consistency evaluation. A wide melting range may indicate the presence of impurities. |
| Nuclear Magnetic Resonance (1H NMR / 13C NMR) | Nuclear Magnetic Resonance Spectroscopy | Using CDCl₃ or DMSO-d₆ as solvent, record 1H and 13C NMR spectra to confirm molecular structure and assign characteristic peaks (e.g., pyrazole ring protons, pinacol methyl peaks), useful for structural confirmation and impurity identification. |
| Thin Layer Chromatography (TLC) | Thin Layer Chromatography | Use silica gel plates with developing solvents such as n-hexane:ethyl acetate (3:1), visualize under UV light (254 nm) or iodine vapor. Useful for rapid impurity screening or monitoring reaction progress; simple but less sensitive. |
| Heavy Metals | ICP-MS or Atomic Absorption Spectroscopy (AAS) | Sample is ashed or digested, followed by detection of heavy metals such as lead, cadmium, mercury, and arsenic using inductively coupled plasma mass spectrometry (ICP-MS), complying with ICH Q3D or pharmacopoeial limits (e.g., ≤10 ppm). |
| Particle Size Distribution (if applicable) | Laser Diffraction | For solid powder products, particle size distribution is measured to ensure process consistency, especially when used as an intermediate in formulations to control flowability and solubility. |
| Stability (Degradation Products) | HPLC-MS Coupled Technique | Uses HPLC coupled with mass spectrometry (LC-MS/MS) to identify degradation products from oxidation, hydrolysis, or deboronation reactions. Useful for forced degradation studies and stability testing to evaluate molecular stability. |
Technical Specifications of 4-Pyrazoleboronic acid pinacol ester
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 125–129°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Pyrazoleboronic acid pinacol ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Pyrazoleboronic acid pinacol ester
Safety Information of 4-Pyrazoleboronic acid pinacol ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Pyrazoleboronic acid pinacol ester
Industrial 4-Pyrazoleboronic acid pinacol ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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