1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 27074-03-9 |
| Product name | 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Antimicrobial drug intermediate | Key cyclic intermediate for synthesizing third-generation quinolone antibiotics (e.g., gatifloxacin); used to construct the quinolone core via N-alkylation, fluorination, and related steps |
Manufacturing Quality Control of 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Chemical Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Utilizes ¹H-NMR and ¹³C-NMR to analyze chemical shifts and coupling constants of hydrogen and carbon atoms, confirming molecular framework and substitution positions. |
| Fourier Transform Infrared Spectroscopy (FT-IR) | Detects characteristic functional group absorption peaks (e.g., nitrile -C≡N ~2200 cm⁻¹, hydroxyl -OH ~3200–3500 cm⁻¹) to assist in structural verification. | |
| Mass Spectrometry (MS) | Employs ESI or EI ionization sources to determine molecular ion peaks ([M+H]⁺ or M⁺•), confirming molecular weight and fragmentation patterns to support structural elucidation. | |
| Purity Analysis | High-Performance Liquid Chromatography (HPLC) | Uses C18 reversed-phase column with UV detector (e.g., 254 nm or set according to maximum absorbance wavelength) for quantitative determination of main component and detection of related impurities. |
| Ultra-Performance Liquid Chromatography (UPLC) | Enhances separation efficiency and speed, suitable for rapid purity assessment and trace impurity analysis. | |
| Content Determination | HPLC External Standard Method / Internal Standard Method | Quantifies target compound content by comparing peak areas with known concentration reference standards, ensuring batch-to-batch consistency. |
| Impurity Limit Testing | HPLC Gradient Elution Method | Optimizes mobile phase gradient programs to separate and quantify potential process impurities, degradation products, etc., meeting ICH Q3A/B requirements. |
| Residual Solvent Testing | Headspace Gas Chromatography (HS-GC) | Performs qualitative and quantitative analysis of organic solvents (e.g., methanol, acetonitrile, DMF) potentially remaining from synthesis, in accordance with ICH Q3C guidelines. |
| Drying Loss / Moisture Content | Karl Fischer Titration | Determines moisture content in samples to prevent adverse effects on stability or reactivity. |
| Drying Loss Method | Dries the sample at a specified temperature until constant weight, calculating total volatile substances (including water and other volatile components). | |
| Melting Point Determination | Capillary Melting Point Apparatus | Measures the melting temperature range as a physical constant for preliminary identification and purity assessment (pure compounds exhibit narrow melting ranges). |
| Polymorphism/Solid-State Characterization | X-Ray Powder Diffraction (XRPD) | Analyses crystal structure-specific diffraction peaks to confirm the presence or absence of polymorphic forms, ensuring consistency in formulation performance. |
| pH Value / Acidity/Alkalinity | pH Meter Measurement (in Solution State) | Prepares a solution of the sample at a defined concentration and measures its pH value to evaluate acid-base properties and their impact on formulations. |
| Heavy Metal Residue | ICP-MS or Atomic Absorption Spectroscopy (AAS) | Tests for elemental impurities such as lead, arsenic, cadmium, and mercury according to pharmacopoeial general rules, ensuring compliance with safety limits (e.g., ICH Q3D). |
Technical Specifications of 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 178–182°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one
Safety Information of 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one
Industrial 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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