Glycine tert butyl ester hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 27532-96-3 |
| Product name | Glycine tert butyl ester hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Glycine tert butyl ester hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Glycine tert butyl ester hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Glycine tert butyl ester hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Synthesis of peptides and pharmaceutical intermediates | Used as a protected amino acid in solid-phase or solution-phase peptide synthesis; the tert-butyl ester group is selectively cleavable |
| Organic Synthesis | Construction of glycine-containing compounds | Acts as a glycine derivative in condensation reactions to form amide bonds |
| Biochemistry | Protein modification and preparation of labeling reagents | Introduces a protected glycine unit, facilitating subsequent deprotection and conjugation |
| Agrochemical R&D | Intermediate for agrochemicals | Participates in the construction of nitrogen-containing heterocycles or amino alcohol-based pesticide molecules |
| Materials Science | Synthesis of functionalized polymer monomers | Serves as a functional amino acid monomer precursor for preparing stimuli-responsive materials |
Manufacturing Quality Control of Glycine tert butyl ester hydrochloride
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) Nuclear Magnetic Resonance Hydrogen Spectroscopy (¹H NMR) |
Compare characteristic absorption peaks in IR spectra (e.g., N–H, C=O, C–O) or ¹H NMR chemical shifts (e.g., singlet of tert-butyl group, multiplets of methylene protons, amino protons) with reference spectra to confirm compound structure. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) Acid-Base Titration |
HPLC: Use a reversed-phase C18 column with a buffer-solvent mobile phase, detect at UV wavelength (typically around 210 nm), and calculate the main component content using external standard method. Acid-Base Titration: Utilize the acidity of the hydrochloride salt; titrate with standardized sodium hydroxide solution, determining the endpoint via phenolphthalein indicator or potentiometric method, then calculate total alkalinity. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use gradient or isocratic HPLC methods to separate and detect potential process impurities (e.g., unreacted glycine, tert-butanol residue), degradation products (e.g., glycine formed by hydrolysis), and other organic impurities. Quantification is typically performed using area normalization or the main component self-control method with correction factors. |
| Water Content | Karl Fischer Titration | Apply either volumetric or coulometric Karl Fischer titration to accurately determine moisture content, suitable for compounds containing crystalline water or exhibiting hygroscopic properties, such as hydrochloride salts. |
| Residual Solvents | Gas Chromatography (GC) | Follow ICH Q3C guidelines; use headspace or direct injection GC with FID detection to identify and quantify organic solvents potentially remaining from manufacturing processes (e.g., dichloromethane, methanol, ethanol, tert-butanol). |
| Drying Loss | Thermogravimetric Analysis (TGA) or Constant Temperature Drying at Atmospheric Pressure | Dry the sample at a specified temperature (e.g., 105°C) until constant weight is achieved, measuring mass loss to assess total volatile substances (including moisture and low-boiling solvents). |
| Residue on Ignition / Ash Content | High-Temperature Incineration Method | Char the sample, then ignite at 700–800°C in a high-temperature furnace until constant weight, to determine residual inorganic impurities, used for controlling inorganic salts or metal catalyst residues. |
| pH Value | pH Meter Measurement | Dissolve the sample in water at a defined concentration (e.g., 1% w/v), measure pH using a calibrated pH meter, reflecting the acidity strength of the hydrochloride salt and possible presence of free acid or base impurities. |
| Specific Rotation (if applicable) | Polarimeter Method | If chiral centers are introduced during derivatization (note: glycine itself is achiral, but derivatives may be chiral), specific rotation can be measured using a polarimeter to verify optical purity. |
Technical Specifications of Glycine tert butyl ester hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142-146°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Glycine tert butyl ester hydrochloride
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NMR Spectra of Glycine tert butyl ester hydrochloride
Safety Information of Glycine tert butyl ester hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Glycine tert butyl ester hydrochloride
Industrial Glycine tert butyl ester hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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