2,6-Difluorophenol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 28177-48-2 |
| Product name | 2,6-Difluorophenol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2,6-Difluorophenol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2,6-Difluorophenol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2,6-Difluorophenol
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of fluoroquinolone antibiotics (e.g., ofloxacin, levofloxacin) | Serves as a starting material; fluorination and condensation reactions construct the drug molecule backbone |
| Pharmaceuticals | Intermediate in the synthesis of agrochemicals and plant growth regulators | Used to construct fluorinated aromatic structures via coupling or substitution reactions |
| Agrochemicals | Synthesis of fluorinated fungicides or herbicides | Undergoes derivatization reactions leveraging its fluorinated phenol structure |
| Materials Science | Synthesis of specialty polymeric materials (e.g., high-temperature-resistant fluoropolymers) or fine chemicals | Acts as a monomer or modifier in polymerization or functionalization reactions |
Manufacturing Quality Control of 2,6-Difluorophenol
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Analyzes using a C18 reversed-phase column, with methanol-water or acetonitrile-water as the mobile phase. Detection is performed using a UV detector at 254 nm. Quantification of the main component is achieved by external or internal standard methods, suitable for high-precision quantitative analysis. |
| Impurity Profile (Organic Impurities) | High-Performance Liquid Chromatography (HPLC) | Employs a gradient elution program to detect potential unreacted raw materials (e.g., fluorophenol isomers), by-products (e.g., difluoroquinone), or degradation products. Qualitative and quantitative analysis is performed by comparing retention times and peak areas with reference standards. |
| Water Content | Karl Fischer Titration | Determines trace moisture based on the quantitative reaction of iodine and sulfur dioxide with water in a solution of pyridine and methanol. Water content is measured using electrochemical or volumetric methods, compliant with pharmacopeia standards (e.g., USP/EP), with a precision down to ppm levels. |
| Volatile Organic Impurities | Gas Chromatography (GC) | Analysis is carried out using a capillary column (e.g., DB-5 or HP-INNOWAX) with an FID detector. Headspace or direct injection is used to detect residual solvents (e.g., methanol, acetone, DMF), suitable for compliance with ICH Q3C guidelines. |
| Fluorine Content | Ion Selective Electrode (ISE) or Ion Chromatography (IC) | After alkaline fusion or acid digestion of the sample to release fluoride ions, the total fluorine content is determined using a fluoride ion selective electrode or ion chromatography (with an anion column), to verify whether the fluorine content matches the theoretical value (C₆H₄F₂O). |
| Melting Point | Melting Point Apparatus | The melting point range is determined using the capillary method or an automatic melting point instrument (literature value approximately 48–50 °C). This is used for preliminary identification and purity evaluation; impurities may cause a depression or broadening of the melting point. |
| Appearance and Color | Visual Inspection + Spectrophotometry | Observe the physical state (white to light yellow crystals). If necessary, use a UV-Vis spectrophotometer to measure absorbance below 500 nm to assess the content of colored impurities (e.g., oxidation products). |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After wet digestion of the sample, AAS is used to determine heavy metals such as Pb, Cd, Hg, and As, or ICP-MS is used for simultaneous multi-element detection, compliant with pharmaceutical standards (e.g., ICH Q3D). |
| pH Value (Aqueous Solution) | pH Meter | Prepare a 1% aqueous solution of the sample and measure the pH using a calibrated pH meter. This is used to assess acidity/basicity and the influence of water-soluble impurities (2,6-difluorophenol is a weak acid, pKa ≈ 7.5). |
Technical Specifications of 2,6-Difluorophenol
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or lumps |
| Purity | >=98.0% (GC) |
| Melting Point | 56.0–59.0°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2,6-Difluorophenol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2,6-Difluorophenol
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Industrial 2,6-Difluorophenol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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