N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 286961-14-6 |
| Product name | N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 286961-14-6
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 286961-14-6 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 286961-14-6
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for synthesizing pyridine-containing drug molecules, such as protease inhibitors and kinase inhibitors | Used in Suzuki-Miyaura cross-coupling reactions with aryl or alkenyl halides to construct C–C bonds and introduce the tetrahydropyridine scaffold |
| Pharmaceuticals | Building block for nitrogen-containing heterocyclic drug candidates to enhance biological activity and selectivity | Applied as a boronate nucleophile in palladium-catalyzed coupling with haloarenes to enable diverse molecular synthesis |
| Chemical Research | Organic synthesis building block for developing novel nitrogen-containing heterocyclic compound libraries | Employed in palladium-catalyzed coupling reactions under anhydrous, oxygen-free conditions for high-throughput screening of lead compounds |
Manufacturing Quality Control of 286961-14-6
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe sample color, physical state (e.g., white to off-white crystalline powder), and presence of foreign matter under natural light or standard illumination. |
| Identification | Proton Nuclear Magnetic Resonance (¹H NMR) Infrared Spectroscopy (IR) Mass Spectrometry (MS) |
Use ¹H NMR to compare characteristic chemical shifts (e.g., tert-butyl signal from Boc group, olefinic protons, methyl signals from pinacol ester); IR confirms functional groups (e.g., C=O from Boc, B–O bond); MS verifies molecular ion peak ([M+H]⁺ or [M+Na]⁺). |
| Purity / Related Substances | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with gradient elution of acetonitrile-water or methanol-water as mobile phase, detected by UV detector (typically 210–254 nm). Quantify main component and impurities using area normalization for purity or external standard method. |
| Water Content | Karl Fischer Titration | Determine moisture content quantitatively via reaction with KF reagent using coulometric or volumetric methods; control impact of hygroscopicity on material stability. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with polar or non-polar capillary columns and FID detection. Analyze residual organic solvents (e.g., dichloromethane, toluene, ethanol) according to ICH Q3C guidelines from synthesis or purification processes. |
| Melting Point | Capillary Melting Point Determination | Determine the temperature range from initial melting to complete melting using a melting point apparatus; serve as a physical constant to assist in assessing purity and consistency. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After sample digestion, determine trace levels of heavy metals such as lead, arsenic, cadmium, and mercury, ensuring compliance with pharmacopoeial or ICH Q3D limits. |
| Boron Content | Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) or Titration | Used to confirm the presence and content of boron element, verifying structural integrity—particularly important for quality control of boron-containing drug intermediates. |
Technical Specifications of 286961-14-6
| Test Item | Specification |
|---|---|
| Appearance | White to orange to green crystalline powder |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 120–125°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 286961-14-6
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 286961-14-6
Packaging of 286961-14-6
Industrial 286961-14-6 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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