4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 28783-41-7 |
| Product name | 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for central nervous system (CNS) drugs, used in synthesizing candidate selective 5-HT6 receptor antagonists | Used as a key chiral building block in multi-step coupling and cyclization reactions; typically prepared via Boc protection, lithiation–electrophilic trapping, and HCl-mediated deprotection to yield the target active pharmaceutical ingredient (API) |
Manufacturing Quality Control of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Compare the infrared absorption spectrum of the sample with a reference spectrum to confirm the presence of characteristic functional groups (e.g., C–Cl, C=N, thiophene ring). |
| High-Performance Liquid Chromatography (HPLC) | Under specific chromatographic conditions, compare the retention time of the test sample with that of the reference standard for preliminary structural confirmation. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with phosphate buffer-acetonitrile or methanol as the mobile phase, and UV detection (approximately 220–254 nm) for quantification of the main component. |
| Non-aqueous Titration | Perform titration in anhydrous glacial acetic acid medium using perchloric acid as titrant and crystal violet as indicator to determine the content of basic nitrogen in hydrochloride salts. | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Employ gradient or isocratic elution programs to separate and quantify potential process impurities and degradation products (e.g., oxides, dechlorinated products). |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with polar or non-polar capillary columns and FID detection to identify residual organic solvents from synthesis (e.g., dichloromethane, methanol, ethanol). |
| Drying Loss | Thermogravimetric Analysis / Oven Drying Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight to determine the percentage loss due to moisture and volatile substances. |
| Residue on Ignition / Ash Content | High-Temperature Ignition Method | Ignite the sample at high temperature (approximately 700–800°C), then weigh the remaining inorganic residue to assess the level of inorganic impurities. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, use AAS or inductively coupled plasma mass spectrometry (ICP-MS) to determine levels of heavy metals such as lead, cadmium, mercury, and arsenic. |
| pH Value | pH Meter Method | Prepare a solution at a defined concentration (e.g., 1%), then measure its acidity or alkalinity using a calibrated pH meter to reflect the dissociation characteristics of the hydrochloride salt. |
| Polymorphism / Crystal Habit | X-Ray Powder Diffraction (XRPD) | Determine the presence of polymorphic forms by analyzing characteristic diffraction peaks to ensure consistent crystal form. |
| Optical Purity (if applicable) | Chiral High-Performance Liquid Chromatography | If chiral centers are present, use a chiral stationary phase column to separate enantiomers and assess optical purity. |
Technical Specifications of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 185-190°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
Safety Information of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
Industrial 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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