tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 289042-12-2 |
| Product name | tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 289042-12-2
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 289042-12-2 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 289042-12-2
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for the novel cholesterol-lowering drug alirocumab | Serves as the starting material for synthesizing the side-chain structural unit of the PCSK9 inhibitor alirocumab; the monoclonal antibody modification fragment is constructed via deprotection, hydrolysis, and coupling steps |
Manufacturing Quality Control of 289042-12-2
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Determine the infrared absorption spectrum of the sample and compare with standard reference spectra to confirm the consistency of functional group characteristic peaks. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze chemical shifts, integration areas, and coupling constants of hydrogen atoms to verify molecular structural features. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with a specific gradient elution program; determine the main component content by external standard method or area normalization. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Employ high-resolution HPLC conditions to separate and quantify potential process impurities and degradation products, controlling both individual and total impurity limits. |
| Residual Solvents | Gas Chromatography (GC) | Utilize headspace or direct injection with capillary column separation and FID detection to quantify common organic solvents (e.g., methanol, ethanol, dichloromethane). |
| Drying Loss | Thermogravimetric Analysis (TGA) or Drying Loss Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight, measuring mass loss to assess moisture and volatile components. |
| Charring Residue / Ash Content | Charring Residue Test Method | Incinerate the sample at high temperature (approximately 700–800°C), weigh the residual inorganic matter to control total inorganic impurity levels. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, determine the content of heavy metals such as lead, cadmium, mercury, and arsenic using AAS or Inductively Coupled Plasma Mass Spectrometry (ICP-MS). |
| Moisture Content | Karl Fischer Titration (KFT) | Use the specific KF reaction to quantitatively determine water content in samples, suitable for moisture-sensitive organic compounds. |
| Optical Purity (if applicable) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | If the intermediate contains chiral centers, use a chiral column to separate enantiomers and ensure optical purity meets required specifications. |
| pH Value (if tested in solution) | pH Meter Measurement | Dissolve the sample in a specified solvent (e.g., water/methanol mixture), then measure the acidity or alkalinity using a calibrated pH meter. |
Technical Specifications of 289042-12-2
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.5% (LC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | +4.5 to +5.5° (c=1, in CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 289042-12-2
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 289042-12-2
Packaging of 289042-12-2
Industrial 289042-12-2 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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