China Factory Direct
|
|
| CAS number | 298716-03-7 |
| Product name | (1R,4R)-4-(tert-butoxycarbonylamino)cyclopent-2-enecarboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Synthesis | Used as a chiral intermediate in the synthesis of targeted therapeutics, including anticancer and neurologic disease drugs | Constructs cyclopentene derivatives with defined stereochemistry via multi-step synthesis using Boc protection of the amino group |
| Organic Synthesis | Used to synthesize nitrogen-containing heterocyclic compounds with specific stereochemical configurations | Enables selective functional group transformation and coupling reactions by leveraging the reversible Boc protecting group |
| Peptide Synthesis | Serves as a precursor to amino acid analogs for incorporation of non-natural amino acids | Extends peptide chains through deprotection and coupling steps in solid-phase or solution-phase peptide synthesis |
| Advanced Materials | Used to prepare functional polymers exhibiting biological activity or specialized physical properties | Incorporates the compound into the polymer backbone via polymerization to modulate material degradability and biocompatibility |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separates enantiomers on a chiral stationary phase and determines (1R,4R) isomer content via peak area ratio relative to total enantiomeric peaks. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., ethyl acetate, heptane) using gas chromatography with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration | Measures trace water by coulometric or volumetric titration where iodine reacts stoichiometrically with water in a pyridine-methanol solvent system. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, As) after acid digestion using inductively coupled plasma mass spectrometry with isotopic detection. |
| Residual BOC Reagent | GC-MS | Identifies and quantifies residual di-tert-butyl dicarbonate by gas chromatography coupled with mass spectrometric detection and selective ion monitoring. |
| Acid Value | Acid-Base Titration | Determines free carboxylic acid content by titration with standardized NaOH solution using phenolphthalein or potentiometric endpoint detection. |
| Optical Rotation | [alpha]D Measurement | Measures specific rotation at 589 nm (Na D-line) in solution to confirm chiral integrity and batch-to-batch consistency of the (1R,4R) configuration. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder particle size distribution by measuring angular variation in laser light scattering intensity across a defined size range. |
| Residual Palladium | ICP-OES | Quantifies palladium catalyst residue after microwave-assisted digestion using inductively coupled plasma optical emission spectroscopy at characteristic wavelengths. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., deprotected amine, decarboxylated product) using gradient HPLC with UV detection. |
| Microbial Contamination | Membrane Filtration | Tests for aerobic microorganisms by filtering sample solution through a sterile membrane, then culturing on soybean-casein digest agar under controlled conditions. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Optical Rotation | +28.0 to +32.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
|
|
|
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.