2-CHLORO-4-PHENYLQUINAZOLINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 29874-83-7 |
| Product name | 2-CHLORO-4-PHENYLQUINAZOLINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-CHLORO-4-PHENYLQUINAZOLINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-CHLORO-4-PHENYLQUINAZOLINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-CHLORO-4-PHENYLQUINAZOLINE
| Industry | Application | Process |
|---|---|---|
| Pesticides | Herbicide intermediate | Used in the synthesis of sulfonylurea herbicides such as bispyribac-sodium, via multi-step reactions including sulfonation and amination to construct the quinazolinesulfonylurea scaffold |
| Pharmaceuticals | Intermediate for anticancer drug research | Serves as a core structural scaffold for modifying lead compounds targeting kinases (e.g., EGFR inhibitors), typically undergoing nucleophilic substitution at the C2-chloro position to introduce pharmacophores |
| Materials Science | Precursor for organic optoelectronic functional materials | Applied in synthesizing quinazoline-based electron-transport materials or fluorescent dyes; aryl or heteroaryl groups are introduced at the C4 position via Suzuki coupling or Ullmann reaction to tune HOMO/LUMO energy levels |
Manufacturing Quality Control of 2-CHLORO-4-PHENYLQUINAZOLINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-UV | Separation and quantification of structurally related impurities using gradient HPLC/UPLC with UV detection; identification via retention time matching and/or spiked standards. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, dichloromethane, toluene) based on calibrated response factors. |
| Heavy Metals (Total) | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppb sensitivity. |
| Chloride Content | Ion Chromatography (IC) | Separation and conductivity-based quantification of chloride anion in aqueous extract; detects residual inorganic chloride from synthesis. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-phase transition temperature range using calibrated capillary apparatus per USP <741>. |
| Loss on Drying (LOD) | Gravimetric Thermobalance (TGA or LOD Analyzer) | Measurement of mass loss upon heating under controlled conditions (e.g., 105 °C, 2 h) to assess volatile content including water and solvents. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration with iodine generation to quantify trace water content based on stoichiometric reaction with Karl Fischer reagent. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Ashing | Weighed sample ignited at 600–700 °C after sulfuric acid treatment; residue weight reflects inorganic impurities. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using Mie scattering theory to determine volumetric particle size distribution (D10, D50, D90). |
Technical Specifications of 2-CHLORO-4-PHENYLQUINAZOLINE
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 192-196°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-CHLORO-4-PHENYLQUINAZOLINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-CHLORO-4-PHENYLQUINAZOLINE
Packaging of 2-CHLORO-4-PHENYLQUINAZOLINE
Industrial 2-CHLORO-4-PHENYLQUINAZOLINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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