N-Acetyl-L-isoleucine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 3077-46-1 |
| Product name | N-Acetyl-L-isoleucine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Acetyl-L-isoleucine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Acetyl-L-isoleucine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Acetyl-L-isoleucine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a chiral intermediate in the synthesis of antibiotics and amino acid-based drugs | Prepared via N-acetylation of L-isoleucine with acetic anhydride under basic conditions |
| Chemical Synthesis | Employed as a chiral auxiliary or ligand in asymmetric synthesis | Obtained through enzymatic or chemoselective acetylation of L-isoleucine |
| Biochemical Research | Used as a reference standard in amino acid metabolism studies | Chemically synthesized material purified by high-performance liquid chromatography (HPLC) serves as an analytical standard |
| Pharmaceutical Intermediates | Applied in the synthesis of biologically active peptides | Used as a protected amino acid derivative in solid-phase peptide synthesis (SPPS) |
Manufacturing Quality Control of N-Acetyl-L-isoleucine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 200-220 nm, comparing peak area against a certified reference standard. |
| Optical Rotation | [alpha]D | Measurement of specific optical rotation using a polarimeter at 20-25 C and sodium D-line (589 nm) to confirm stereochemical integrity. |
| Loss on Drying | Gravimetric (Thermogravimetry) | Mass loss determined after drying at 105 C for 2 hours under atmospheric pressure, reflecting volatile content including residual solvents and moisture. |
| Residual Solvents | GC-FID | Separation and quantification of common organic solvents (e.g., methanol, ethanol, acetone) using gas chromatography with flame ionization detection. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) by inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode to determine chloride ion concentration based on precipitation endpoint. |
| Sulfate Content | Turbidimetric Method | Formation of barium sulfate precipitate in acidic medium; quantification via measurement of turbidity at 420 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities (e.g., N-acetyl-L-leucine, N-acetyl-D-isoleucine, degradants) using gradient HPLC-UV. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Determination of pH in a 1% w/v aqueous solution using calibrated pH meter with glass electrode. |
| Melting Point | Capillary Melting Point Apparatus | Observation of solid-to-liquid transition range using capillary tube method per USP <741>. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric determination of water content based on iodine-sulfur dioxide reaction in pyridine/methanol medium. |
| Microbial Contamination | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, Salmonella) per USP <61> and <62>. |
Technical Specifications of N-Acetyl-L-isoleucine
| Test Item | Specification |
|---|---|
| Appearance | White to Off-White Powder or Crystals |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 138–142°C |
| Optical Rotation | +14.5 to +15.5°, c=1 in ethanol |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Acetyl-L-isoleucine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Acetyl-L-isoleucine
Packaging of N-Acetyl-L-isoleucine
Industrial N-Acetyl-L-isoleucine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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