(R)-3-(Boc-Amino)piperidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 309956-78-3 |
| Product name | (R)-3-(Boc-Amino)piperidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-3-(Boc-Amino)piperidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-3-(Boc-Amino)piperidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-3-(Boc-Amino)piperidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Synthesis | Intermediate in the synthesis of antipsychotic, antidepressant, and other central nervous system agents | Used as a chiral amine precursor; after Boc protection, participates in multistep condensation and coupling reactions to construct complex drug molecules |
| Organic Synthesis | Precursor to chiral catalysts or ligands | Introduced into asymmetric synthesis reactions via deprotection or functional group transformation to establish chiral centers |
| Biopharmaceutical R&D | Advanced pharmaceutical intermediate for targeted drug design and lead compound optimization | Applied during drug discovery to construct piperidine scaffolds, enhancing potency and selectivity |
| Chemical Reagents | Specialized reagent for laboratory-scale chemical reactions | Employed as a nitrogen source or structural building block in key steps including cyclization, alkylation, and acylation |
Manufacturing Quality Control of (R)-3-(Boc-Amino)piperidine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Chemical Purity | High-Performance Liquid Chromatography (HPLC) | Utilizes a reverse-phase chromatography column with a UV detector (e.g., at 210 nm or 220 nm) to detect the peak area of the main component, evaluating the relative content of the target compound in the sample. |
| Enantiomeric Purity (Optical Purity) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Employs a chiral stationary phase column to separate enantiomers; the enantiomeric excess (ee value) is calculated by comparing the peak areas of the (R) and (S) isomers to ensure compliance with chiral purity specifications. |
| Water Content | Karl Fischer Water Determination | Uses coulometric or volumetric titration to precisely measure trace water content in the sample, ensuring compliance with drying loss or water content standards (typically ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Employs headspace or direct injection GC-FID/MS, following ICH Q3C guidelines, to quantitatively detect residual organic solvents (e.g., methanol, ethyl acetate, dichloromethane) from the synthesis process. |
| Residue on Ignition / Ash Content | Incineration Method | The sample is incinerated at high temperature (e.g., 700–800°C) to constant weight to determine the amount of inorganic impurities, assessing levels of inorganic salts or metal catalyst residues. |
| Heavy Metal Content | ICP-MS or Atomic Absorption Spectroscopy (AAS) | Quantitatively analyzes harmful heavy metal elements such as lead, cadmium, mercury, and arsenic using inductively coupled plasma mass spectrometry or atomic absorption spectroscopy, in accordance with ICH Q3D limits. |
| Appearance | Visual Inspection + Microscopic Observation | Examines sample color, crystalline form, and whether agglomeration or moisture absorption has occurred; should appear as a white to off-white crystalline powder, meeting physical property specifications. |
| Melting Point | Capillary Melting Point Apparatus | Measures the melting temperature range of the sample and compares it with literature values (e.g., approximately 75–78°C) as an auxiliary indicator for identification and purity assessment. |
| Specific Rotation | Polarimeter Measurement | Measures optical rotation at a specified wavelength (typically 589 nm, sodium D-line) and concentration to calculate specific rotation [α]D, verifying chiral configuration and optical activity. |
| Structural Confirmation | Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), Infrared Spectroscopy (IR) | Comprehensive comparison of 1H-NMR, 13C-NMR, HRMS, and FT-IR spectra with reference spectra to confirm molecular structure, functional groups, and integrity of the Boc protecting group. |
Technical Specifications of (R)-3-(Boc-Amino)piperidine
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (GC-MS); >=99% ee |
| Optical Rotation | +13.0 to +16.0 deg (c=1, in CHCl3) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78 to 82 °C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-3-(Boc-Amino)piperidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-3-(Boc-Amino)piperidine
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Industrial (R)-3-(Boc-Amino)piperidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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