L(-)-Pipecolinic acid Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 3105-95-1 |
| Product name | L(-)-Pipecolinic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for L(-)-Pipecolinic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk L(-)-Pipecolinic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of L(-)-Pipecolinic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key chiral intermediate for the synthesis of the antihypertensive drug perindopril | Prepared via chemical cyclization of L-lysine or microbial fermentation, followed by acid hydrolysis and purification |
| Pharmaceutical Intermediates | Side-chain building block for the synthesis of the angiotensin-converting enzyme (ACE) inhibitor quinapril | Undergoes amidation with appropriate acyl chlorides or anhydrides; subsequent introduction of specific substituents enables coupling |
| Fine Chemicals | Precursor to chiral catalyst ligands for asymmetric synthesis reactions | After protection and derivatization, coordinates to metal centers for catalytic processes such as hydrogenation and epoxidation |
| Pesticide R&D | Chiral structural unit for novel chiral herbicides and insecticides | Functional group transformations introduce heterocyclic or halogen moieties to construct biologically active, target-specific molecules |
Manufacturing Quality Control of L(-)-Pipecolinic acid
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection + Physical Property Determination | Observe sample color and state (typically white crystalline powder), determine melting point (literature value approximately 195–200 °C), and assess compliance with pharmacopoeial or internal quality standards. |
| Identification | Infrared Spectroscopy (IR) | Compare characteristic IR absorption peaks (e.g., C=O stretching vibration of carboxyl group at ~1710 cm⁻¹, N–H bending vibration at ~1550 cm⁻¹) with reference spectra to confirm structural identity. |
| Identification | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with water-methanol or buffer as mobile phase; compare retention time with that of the reference standard for qualitative identification. Detection can be performed using a UV detector (210–220 nm). |
| Identification | Thin-Layer Chromatography (TLC) | Use silica gel plates with developing solvent such as n-butanol–glacial acetic acid–water (4:1:1); visualize spots using ninhydrin reagent. Confirm identity by matching Rf values with those of the reference standard—suitable for rapid qualitative analysis. |
| Assay | High-Performance Liquid Chromatography (HPLC) | Quantify using external or internal standard method based on peak area. Linear range is typically 1–200 μg/mL, detection wavelength at 210–220 nm. High accuracy, suitable for raw material assay (e.g., ≥98.0%). |
| Assay | Acid-Base Titration | Titrate the carboxylic acid group with sodium hydroxide standard solution using phenolphthalein as indicator, then calculate content. Suitable for rough estimation but prone to interference from impurities; often used in preliminary quality control. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use gradient elution to detect structurally related impurities (e.g., D-2-piperidinecarboxylic acid, piperidine, unreacted starting materials). Employ principal component self-reference method or external standard method to control individual impurity ≤0.5% and total impurities ≤1.0%. |
| Water Content | Karl Fischer Titration | Determine trace moisture using coulometric or volumetric method. Control water content ≤1.0% to prevent hygroscopicity-related instability and solubility issues. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with polar columns like DB-624 to detect residual organic solvents (e.g., ethanol, acetone, acetonitrile). Comply with ICH Q3C guidelines (e.g., ethanol ≤5000 ppm). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Digest the sample and measure concentrations of heavy metals such as lead, cadmium, mercury, and arsenic. Must meet pharmacopoeial limits (e.g., Pb ≤5 ppm). |
| Optical Rotation | Polarimetry | L-2-Piperidinecarboxylic acid is chiral. Prepare a solution of defined concentration (e.g., 10 mg/mL in water) and measure specific optical rotation (literature value approximately -5° to -10°) to verify optical purity and rule out contamination with the D-isomer. |
| Solution Clarity and Color | Visible Spectrophotometry / Visual Comparison | Prepare a solution at specified concentration and measure absorbance in the visible range (400–700 nm), or compare visually with standard color solutions to ensure absence of turbidity or colored impurities. |
| Microbial Limits | Plate Count Method / MPN Method | Test total aerobic microbial count, molds and yeasts, and presence of *Escherichia coli* according to pharmacopoeial requirements. Applicable for non-sterile active pharmaceutical ingredients to control levels of biological contamination. |
Technical Specifications of L(-)-Pipecolinic acid
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178-182°C |
| Optical Rotation | -25.0 to -28.0° (c=1, H2O) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of L(-)-Pipecolinic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of L(-)-Pipecolinic acid
Packaging of L(-)-Pipecolinic acid
Industrial L(-)-Pipecolinic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply