BOC-HIS(BOC)-OH DCHA Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 31687-58-8 |
| Product name | BOC-HIS(BOC)-OH DCHA |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for BOC-HIS(BOC)-OH DCHA
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk BOC-HIS(BOC)-OH DCHA Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of BOC-HIS(BOC)-OH DCHA
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Protecting reagent for histidine residues in peptide synthesis | Used in solid-phase peptide synthesis (SPPS) to selectively protect the imidazole ring of the histidine side chain, preventing side reactions; deprotection under mild conditions (e.g., TFA/DCM), compatible with Fmoc strategy |
Manufacturing Quality Control of BOC-HIS(BOC)-OH DCHA
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity | HPLC (High-Performance Liquid Chromatography) | Uses a reversed-phase C18 column with acetonitrile/water (containing 0.1% TFA) as the mobile phase, and detects the main peak area using a UV detector (e.g., 254 nm). The purity is calculated based on the peak area. This method effectively separates the target compound from impurities and is considered the gold standard for assessing product purity. |
| Molecular Weight Confirmation | LC-MS (Liquid Chromatography-Mass Spectrometry) | Utilizes ESI ionization to determine the molecular ion peak ([M+H]⁺), confirming whether the molecular weight matches the theoretical value (e.g., ~476.6). It can also identify degradation products or by-products. |
| Structure Confirmation | NMR (Nuclear Magnetic Resonance) | Analyzes characteristic signals through ¹H NMR and ¹³C NMR, such as the methyl signal of tert-butoxy carbonyl (Boc) group (~1.4 ppm), histidine imidazole protons, and methylene/methine signals of dicyclohexylamine, to verify structural integrity. |
| Content Determination | UV-Vis Spectrophotometry (e.g., 254 nm) | Based on the absorbance of the compound at a specific wavelength, combined with a standard curve for quantification. Suitable for rapid preliminary screening but requires confirmation with other methods. |
| Residual Solvents | GC (Gas Chromatography) | Uses a capillary column (e.g., DB-624) and FID detector to detect residual organic solvents (e.g., ethanol, acetone, toluene), in compliance with ICH Q3A standards. |
| Water Content | Karl Fischer Titration | Used to determine the content of free water or crystalline water in the sample, ensuring an anhydrous or low-water state to prevent hydrolysis reactions. |
| Acidity/Alkalinity/pH (in solution) | pH Meter Measurement | Measures the pH value of the compound in water or buffer solution, determining whether there are excess acidic or basic impurities that may affect subsequent reaction performance. |
| Melting Point | Melting Point Apparatus Measurement | Determined using a melting point apparatus or differential scanning calorimetry (DSC), used to assess the crystalline state and purity. |
| Residual Metal Ions | ICP-MS (Inductively Coupled Plasma Mass Spectrometry) | Detects trace metal impurities (e.g., Fe, Cu, Pb) to evaluate catalyst residues, meeting pharmaceutical-grade raw material requirements. |
Technical Specifications of BOC-HIS(BOC)-OH DCHA
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142-146°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Optical Rotation | +12.0 to +14.0° (c=1, in 1M HCl) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of BOC-HIS(BOC)-OH DCHA
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of BOC-HIS(BOC)-OH DCHA
Packaging of BOC-HIS(BOC)-OH DCHA
Industrial BOC-HIS(BOC)-OH DCHA Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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