2-Fluoro-3-nitrobenzoic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 317-46-4 |
| Product name | 2-Fluoro-3-nitrobenzoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Fluoro-3-nitrobenzoic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Fluoro-3-nitrobenzoic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Fluoro-3-nitrobenzoic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for antitumor drug synthesis | Used as a fluorinated aromatic compound in coupling reactions to construct active molecular scaffolds |
| Pesticides | Intermediate for insecticide and herbicide synthesis | Applied in the preparation of fluorinated pesticide active ingredients via reduction, acylation, and related reactions |
| Dyes & Pigments | Intermediate for dyes and pigments | Used in diazotization and coupling reactions for the synthesis of high-performance organic pigments |
| Organic Synthesis | Raw material for fluorinated aromatic compound synthesis | Processed through multistep reactions—including nitro group reduction and carboxyl group modification—to prepare functionalized aromatic derivatives |
Manufacturing Quality Control of 2-Fluoro-3-nitrobenzoic acid
| Test Item | Common Test Method | Method Summary |
|---|---|---|
| Appearance and Properties | Visual Inspection + Physical Property Determination | Observe sample color, crystal form, and state (usually white to pale yellow crystalline powder), determine melting point range (literature value approximately 145–150 °C), and ensure compliance with pharmacopoeia or internal quality standards. |
| Melting Point | Capillary Melting Point Method | Determine the melting point using a standard capillary method, compare it with reference standards or literature values to assess purity and crystal form consistency. |
| Content (Main Component Purity) | High-Performance Liquid Chromatography (HPLC) | Use a C18 chromatographic column with water-acetonitrile or methanol as mobile phase (often with 0.1% formic acid or phosphoric acid added to adjust pH), detect with a UV detector at 254 nm or 280 nm, calculate the main peak area percentage using external standard method, usually required to be ≥98.0%. |
| Related Substances (Impurity Profile) | HPLC Method (Gradient Elution) | Separate and quantify possible organic impurities (such as unreacted raw materials, defluorinated products, nitrated by-products, degradation products) using gradient elution program, detect at wavelengths of 220–280 nm, use main component self-control method or external standard method to control single impurity and total impurity limits (e.g., ≤0.5%). |
| Fluorine Content | Ion-Selective Electrode Method (ISE) or Ion Chromatography | F⁻ concentration in solution is determined after alkali fusion or hydrolysis of the sample using a fluoride ion-selective electrode, or quantified through ion chromatography, verifying whether the fluorine atoms in the molecule match the theoretical value (theoretical F content about 10.6%). |
| Nitro Group / Nitrogen Content | Elemental Analysis (EA) or Kjeldahl Method | Determine C, H, N, F content using an elemental analyzer and compare with theoretical values to confirm molecular composition; alternatively, use the Kjeldahl method to measure total nitrogen content to verify the presence and proportion of nitro groups. |
| Water Content | Karl Fischer Titration Method | Determine trace moisture in the sample using volumetric or coulometric methods, controlling moisture content ≤0.5%, to prevent hygroscopicity affecting stability or reactivity. |
| Solvent Residues | Gas Chromatography (GC) | Detect residual organic solvents from the production process (e.g., ethanol, acetone, ethyl acetate, DMF), using headspace injection or direct injection, with FID detector, and control residue levels according to ICH Q3C guidelines. |
| Inorganic Impurities (Chlorides, Sulfates, etc.) | Colorimetric Method or Ion Chromatography | Perform chloride and sulfate limit tests according to pharmacopoeia methods (e.g., ChP/USP), or use ion chromatography to quantify anionic impurities, ensuring inorganic impurities meet safety standards. |
| pH Value (Aqueous Solution) | pH Meter Measurement Method | Prepare a certain concentration (e.g., 1% w/v) aqueous solution of the sample, measure pH with a calibrated pH meter, typically acidic (pH 2–4), reflecting carboxylic acid characteristics and impurity effects. |
| Particle Size Distribution (if applicable) | Laser Diffraction Method or Microscopy | For raw materials requiring control of powder flowability or dissolution rate in formulations, measure particle size distribution to ensure compliance with process requirements (e.g., D90<50 μm). |
Technical Specifications of 2-Fluoro-3-nitrobenzoic acid
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 148-152°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Fluoro-3-nitrobenzoic acid
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| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Fluoro-3-nitrobenzoic acid
Packaging of 2-Fluoro-3-nitrobenzoic acid
Industrial 2-Fluoro-3-nitrobenzoic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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