5-Benzyl L-glutamate N-carboxyanhydride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 3190-71-4 |
| Product name | 5-Benzyl L-glutamate N-carboxyanhydride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Benzyl L-glutamate N-carboxyanhydride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Benzyl L-glutamate N-carboxyanhydride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Benzyl L-glutamate N-carboxyanhydride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Synthesis of drug intermediates | Used in the synthesis of peptide-based drugs or as a protecting group in peptide synthesis |
| Biochemistry | Peptide synthesis | Acts as an active ester in solid-phase or solution-phase peptide synthesis |
| Research | Scientific research | Applied in studies of protein structure and function, as well as reaction mechanisms in peptide chemistry |
| Polymer Chemistry | Synthesis of polymeric materials | Employed as a monomer or crosslinker to synthesize polymeric materials with specific biological activity |
Manufacturing Quality Control of 5-Benzyl L-glutamate N-carboxyanhydride
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Utilizes a reversed-phase C18 column with a gradient elution of acetonitrile/water (containing 0.1% trifluoroacetic acid) and UV detection (210–220 nm). Purity of Glu(OBzl)-NCA is assessed by comparing retention times with reference standards and quantifying peak areas, excluding interference from unreacted starting materials, hydrolysis products, or by-products. |
| Water Content | Karl Fischer Titration | Based on the quantitative reaction of iodine with sulfur dioxide in the presence of pyridine and methanol, this method measures trace water content. Glu(OBzl)-NCA is highly water-sensitive; excessive moisture can cause ring-opening hydrolysis, requiring strict control (typically <0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Employing headspace or direct injection, a DB-WAX or HP-INNOWAX capillary column with FID detection is used to analyze common synthetic solvents such as ethanol, ethyl acetate, and dichloromethane, in compliance with ICH Q3C guidelines. |
| Stability of the Cyclic Anhydride / Degree of Hydrolysis | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Monitors the characteristic absorbance of NCA at 210–230 nm over time in a buffer solution (e.g., pH 7.4 PBS) to evaluate hydrolysis kinetics. Can be combined with HPLC to quantify hydrolysis products such as glutamic acid 5-benzyl ester. |
| Chloride Ions / Inorganic Impurities | Ion Chromatography (IC) | Used to detect chloride ions potentially introduced during synthesis (e.g., from chlorinating reagents such as SOCl₂ or PCl₃), employing an anion-exchange column and conductivity detection to ensure inorganic impurities are below ppm levels. |
| Melting Point / Thermal Stability | Differential Scanning Calorimetry (DSC) | Determines the melting point (typically 70–85°C) and onset temperature of thermal decomposition to assess purity and thermal stability. Multiple melting peaks or premature decomposition indicate the presence of impurities. |
| Nuclear Magnetic Resonance (Structural Confirmation) | Proton Nuclear Magnetic Resonance (¹H NMR) and Carbon Nuclear Magnetic Resonance (¹³C NMR) | Performed in deuterated DMSO or CDCl₃; characteristic peaks confirm molecular structure: benzyl CH₂ (~5.0 ppm), NCA ring carbonyl carbon (~160 ppm), α- and β-methylene protons, etc., verifying correct molecular structure. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Detects heavy metal impurities such as lead, cadmium, mercury, and arsenic to ensure compliance with pharmaceutical-grade standards (e.g., USP/EP <10 ppm), particularly critical when used in drug delivery systems. |
| Appearance and Color | Visual Inspection + Colorimetry | Examines whether the sample is a white to off-white crystalline powder without visible particulates. Color difference meters or colorimetric methods assess the yellow index (YI) to prevent darkening due to oxidation or degradation. |
| Volatile Impurities / Degradation Products | Gas Chromatography-Mass Spectrometry (GC-MS) | Screening for volatile degradation products after heating or storage, such as benzyl alcohol, CO₂, or benzaldehyde, to confirm whether ring-opening or decarboxylation reactions have occurred. |
Technical Specifications of 5-Benzyl L-glutamate N-carboxyanhydride
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.5% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 128–132°C |
| Optical Rotation | -21.0 to -17.0° (c=1, in CHCl3) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Benzyl L-glutamate N-carboxyanhydride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Benzyl L-glutamate N-carboxyanhydride
Safety Information of 5-Benzyl L-glutamate N-carboxyanhydride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5-Benzyl L-glutamate N-carboxyanhydride
Industrial 5-Benzyl L-glutamate N-carboxyanhydride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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