5-Azacytidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 320-67-2 |
| Product name | 5-Azacytidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Azacytidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Azacytidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Azacytidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Treatment of myelodysplastic syndromes (MDS) | Inhibits DNA methylation to restore gene expression |
| Biological Research | As a DNA methyltransferase inhibitor | Applied in cell culture or experimental animal models |
| Drug Development | Used as a lead compound for antitumor drug development | Chemically modified to enhance stability and selectivity |
| Agriculture | Potential use in plant epigenetic regulation studies | Applied to plant materials to monitor changes in gene expression |
Manufacturing Quality Control of 5-Azacytidine
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | A reverse-phase C18 column and UV detector (typically at 270–280 nm) are used with a phosphate buffer-methanol or acetonitrile mobile phase. The main component content is quantified using an external standard method. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | A gradient elution program is used to separate the main peak from impurity peaks. Degradation products (e.g., 5-azauridine, carbamoyl derivatives, etc.) are detected, and the content of each impurity and total impurity is calculated. |
| Residual Solvents | Gas Chromatography (GC) | According to ICH guidelines, organic solvents used in the production process (e.g., methanol, ethanol, dichloromethane, N,N-dimethylformamide, etc.) are detected using headspace sampling. |
| Moisture | Karl Fischer Titration | The water content in the sample is determined using Karl Fischer reagent. This is essential for moisture control in raw materials to ensure stability. |
| Crystalline Form Analysis | X-ray Powder Diffraction (XRPD) | Different crystalline forms or amorphous states are identified to ensure consistency of crystalline form between batches, which affects solubility and stability. |
| Melting Point | Melting Point Apparatus | The melting temperature range of 5-azacytidine is measured. It is used for preliminary identification and purity assessment (note: this compound may decompose). |
| Specific Rotation | Polarimeter | Optical rotation is measured at a specified wavelength (e.g., sodium D line, 589 nm) to assess chiral purity and confirm identity. |
| Solution Clarity and Color | UV-Visible Spectrophotometry / Visual Color Comparison | The sample is prepared as a solution to observe its clarity and color, or absorbance is measured at specific wavelengths to control color. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | Harmful element residues such as lead, cadmium, mercury, and arsenic are measured to comply with pharmacopoeial requirements for elemental impurities (e.g., ICH Q3D). |
| Microbial Limit | Microbial Limit Test | This includes aerobic bacterial count, mold, and yeast counts, as well as control organisms (e.g., Escherichia coli, Salmonella). It applies to non-sterile drug substances. |
| Bacterial Endotoxins | Limulus Amebocyte Lysate (LAL) Assay | If the substance is intended for injectable formulations, bacterial endotoxin levels must be tested to meet safety standards for parenteral use. |
| Content Uniformity/Dissolution | HPLC or UV Spectrophotometry (for dosage forms) | If it is a dosage form product, content uniformity and dissolution testing are required; however, this generally does not apply to active pharmaceutical ingredients (APIs). |
Technical Specifications of 5-Azacytidine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 208-212°C |
| Optical Rotation | +37.3 to +39.7° (c=1, H2O) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Azacytidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Azacytidine
Packaging of 5-Azacytidine
Industrial 5-Azacytidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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