17-Iodoandrosta-5,16-dien-3beta-ol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 32138-69-5 |
| Product name | 17-Iodoandrosta-5,16-dien-3beta-ol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 17-Iodoandrosta-5,16-dien-3beta-ol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 17-Iodoandrosta-5,16-dien-3beta-ol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 17-Iodoandrosta-5,16-dien-3beta-ol
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for synthesizing steroid drugs, used to prepare androstene derivatives with antitumor activity | Converted into the target active molecule via multi-step chemical modifications (e.g., oxidation, substitution) in organic solvents |
| Biochemical Research | Radiolabeled probe (e.g., 125I-labeled) for androgen receptor binding assays | Radioiodine isotope exchange or direct iodination labeling, followed by solid-phase extraction purification |
Manufacturing Quality Control of 17-Iodoandrosta-5,16-dien-3beta-ol
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection, Melting Point Determination | Observe sample color and physical state (typically white or off-white crystalline powder), determine melting point range (literature value approximately 120–130°C) to assess purity and crystallinity. |
| Identification | Infrared Spectroscopy (IR) | Identify characteristic functional group absorption peaks: 3β-OH (~3400 cm⁻¹), C=C (~1600–1650 cm⁻¹), C-I (~500–600 cm⁻¹); compare with reference spectrum for confirmation. |
| Identification | High-Performance Liquid Chromatography (HPLC) | Use C18 column with methanol-water or acetonitrile-water mobile phase; detection wavelength 200–254 nm; identify by comparing retention time with standard reference material. |
| Identification | Mass Spectrometry (MS, ESI or EI) | Utilize LC-MS or GC-MS to detect molecular ion peak [M+H]⁺ or [M]⁺· (theoretical m/z ≈ 418/420 due to ¹²⁷I/¹²⁹I isotopes); fragment ions reflect steroid ring cleavage and iodine loss, confirming molecular structure. |
| Content Determination | High-Performance Liquid Chromatography with UV Detection (HPLC-UV) | Quantitative analysis using external standard or internal standard method; optimize chromatographic conditions to separate impurities; detection wavelength set at 240 nm (absorption from conjugated diene system); linear range typically 0.1–200 μg/mL, R² > 0.999. |
| Impurity Profile Analysis | High-Performance Liquid Chromatography with UV/MS Detection (HPLC-UV/MS) | Gradient elution to separate degradation products (e.g., deiodinated, oxidized, dehydrated derivatives); combine MS for structural elucidation of impurities; control individual impurity ≤0.1%, total impurities ≤0.5% (in line with ICH Q3B guidelines). |
| Iodine Content Determination | Ion Chromatography (IC) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After acid digestion, IC is used to measure iodide ion (I⁻) content, or ICP-MS directly quantifies total iodine; ensure iodine content matches theoretical value (theoretical I% ≈ 30.3%). |
| Solvent Residuals | Gas Chromatography with Flame Ionization Detection (GC-FID) | Test residual solvents (e.g., methanol, ethanol, dichloromethane, acetonitrile) according to ICH Q3C guidelines; use DB-624 capillary column with headspace injection to ensure compliance with specified limits. |
| Moisture Content | Karl Fischer Titration | Accurately determine water content in the sample; control moisture level ≤0.5% (based on formulation requirements) to prevent hydrolysis or crystal hydration issues affecting stability. |
| Optical Rotation | Measurement by Polarimeter | 3β-Hydroxysteroids are chiral; measure specific rotation [α]₂₅D (e.g., +10° to +25°, solvent: ethanol) to confirm stereochemical consistency and optical purity. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect heavy metals such as lead, cadmium, mercury, and arsenic; control levels below ≤10 ppm (per pharmacopoeial general tests) to ensure product safety. |
| Particle Size Distribution (if applicable) | Laser Diffraction Method | If the active pharmaceutical ingredient is used in formulation, particle size distribution must be evaluated to ensure dissolution performance and process compatibility (e.g., spray-dried or micronized products). |
Technical Specifications of 17-Iodoandrosta-5,16-dien-3beta-ol
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 162–166 °C |
| Optical Rotation | -53.0 ± 3.0 ° (c=1, CHCl3) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 17-Iodoandrosta-5,16-dien-3beta-ol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 17-Iodoandrosta-5,16-dien-3beta-ol
Safety Information of 17-Iodoandrosta-5,16-dien-3beta-ol
| Pictograms |    |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 17-Iodoandrosta-5,16-dien-3beta-ol
Industrial 17-Iodoandrosta-5,16-dien-3beta-ol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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