5-Bromo-2-chloropyrimidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 32779-36-5 |
| Product name | 5-Bromo-2-chloropyrimidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Bromo-2-chloropyrimidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Bromo-2-chloropyrimidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Bromo-2-chloropyrimidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Serves as a pyrimidine ring building block for the synthesis of active pharmaceutical ingredients (APIs), including kinase inhibitors (e.g., EGFR inhibitors), antiviral agents, and anticancer drugs. |
| Agrochemicals | Agrochemical Intermediates | Used in the synthesis of pyrimidine-based fungicides and herbicides, functioning as a key structural scaffold in the construction of bioactive molecules. |
| Organic Synthesis | General Synthetic Building Block | Enables nucleophilic aromatic substitution (SNAr) reactions leveraging differential reactivity of halogens (bromine, chlorine) to synthesize diverse substituted pyrimidine derivatives. |
| Research & Development | Biochemical Research | Serves as a precursor for probe molecules or bioactive compounds in drug screening and structure–activity relationship (SAR) studies. |
Manufacturing Quality Control of 5-Bromo-2-chloropyrimidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., 5-bromopyrimidine, 2-chloropyrimidine, bromine-containing dimers) using gradient HPLC-UV. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify residual solvents (e.g., methanol, dichloromethane, toluene) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and other heavy metals after acid digestion and dilution, per USP <231>. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection after aqueous extraction. |
| Bromide Impurity | Ion Chromatography | Separation and quantification of bromide ions using suppressed conductivity detection after aqueous extraction. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid transition temperature range using calibrated capillary apparatus per USP <741>. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of foreign particles under controlled white light and against standard references. |
| Loss on Drying | Gravimetric Analysis | Weight loss measured after drying sample at 105 C for 2 hours under vacuum or nitrogen purge. |
| Acid-Base Impurities | Acid-Base Titration | Titration with standardized NaOH or HCl to detect and quantify acidic or basic impurities by potentiometric endpoint. |
| Particle Size Distribution | Laser Diffraction | Measurement of particle size distribution in dry dispersion mode using Mie theory-based light scattering analysis. |
Technical Specifications of 5-Bromo-2-chloropyrimidine
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 72–76°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Bromo-2-chloropyrimidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Bromo-2-chloropyrimidine
Packaging of 5-Bromo-2-chloropyrimidine
Industrial 5-Bromo-2-chloropyrimidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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