2-Chloro-5-iodopyrimidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 32779-38-7 |
| Product name | 2-Chloro-5-iodopyrimidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Chloro-5-iodopyrimidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Chloro-5-iodopyrimidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Chloro-5-iodopyrimidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Key intermediate for antiviral drugs (e.g., efavirenz) | Constructing structurally complex drug scaffolds via coupling reactions (e.g., Sonogashira coupling), leveraging iodine atom reactivity |
| Pharmaceutical Chemicals | Novel pyrimidine-based pharmaceutical building blocks | Introducing aryl, alkenyl, or alkynyl groups via palladium-catalyzed cross-coupling for screening and developing new drug candidates |
| Agrochemicals | Intermediate for pyrimidine-based fungicides or insecticides | Enabling selective functionalization to synthesize target agrochemical active ingredients, exploiting differential halogen reactivity (Cl vs. I) |
| Organic Synthesis | Synthesis of functional materials and fine chemicals | Serving as a versatile synthon; constructing conjugated systems or specialized organic molecules via metal-catalyzed transformations of the C–I bond |
Manufacturing Quality Control of 2-Chloro-5-iodopyrimidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination based on peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at ~254 nm. |
| Related Substances | HPLC-UV or HPLC-MS | Separation and semi-quantitative/quantitative detection of structurally related impurities (e.g., 2-chloropyrimidine, 5-iodopyrimidine, chlorinated dimers) using gradient elution and UV or mass-selective detection. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify residual solvents (e.g., DMF, THF, methanol, dichloromethane) based on calibrated external standards. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration quantifying water via iodine generation and stoichiometric reaction with water in anhydrous methanol-based reagent. |
| Heavy Metals (as Pb) | ICP-OES | Multi-element trace metal quantification after acid digestion, measuring emission intensities of metal-specific wavelengths following plasma excitation. |
| Chloride Impurity | Ion Chromatography (IC) with Conductivity Detection | Separation of chloride anions on an anion-exchange column and quantification via suppressed conductivity detection relative to calibration standards. |
| Iodine Content | Potentiometric Titration with Sodium Thiosulfate | Oxidative liberation of iodine from the compound (e.g., via NaNO₂/H⁺), followed by redox titration with standardized thiosulfate and endpoint detection using a platinum indicator electrode. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement by observing the temperature range over which solid-to-liquid phase change occurs under controlled heating rate. |
| Appearance & Color | Visual Inspection / Hazen Color Scale | Subjective assessment of physical state (crystalline powder) and quantitative color evaluation against platinum-cobalt standards using spectrophotometric correlation. |
| Residue on Ignition | Gravimetric Analysis (Weight Loss on Ignition) | Determination of inorganic ash content by ignition at 700–800 °C followed by precise weighing of residual non-volatile matter. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity as a function of angle to determine volumetric particle size distribution in dispersed dry or wet samples. |
| Bulk Density | ASTM D1895 Method A (Tapped Density) | Measurement of mass per unit volume for freely settled and then tapped powder, providing bulk and tapped density values for flowability assessment. |
| Microbial Contamination | Membrane Filtration + Culture Enumeration | Sterile filtration of sample suspension, membrane transfer onto selective agar media, incubation, and colony-forming unit (CFU) enumeration per pharmacopeial guidelines (if applicable). |
Technical Specifications of 2-Chloro-5-iodopyrimidine
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 128–132°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Chloro-5-iodopyrimidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Chloro-5-iodopyrimidine
Packaging of 2-Chloro-5-iodopyrimidine
Industrial 2-Chloro-5-iodopyrimidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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