4-[(tert-Butoxycarbonylamino)methyl]benzoic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 33233-67-9 |
| Product name | 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Amino acid protecting intermediate in peptide synthesis | Introduces a protected p-aminobenzyl structure in solid-phase peptide synthesis (SPPS); the Boc group is cleaved under acidic conditions (e.g., TFA) to liberate the free amino group |
| Organic Synthesis | Building block for drug molecules containing both benzoic acid and aminomethyl functionalities | Serves as a key intermediate in coupling reactions (e.g., Suzuki coupling, amide coupling) for synthesizing targeted protein degraders (PROTACs) and kinase inhibitors |
| Bioconjugation | Linker design for antibody–drug conjugates (ADCs) | Couples via its carboxyl group to lysine residues on antibodies, or—after activation—forms an amide bond with the amino group of drug molecules, providing either cleavable or non-cleavable linker scaffolds |
Manufacturing Quality Control of 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities relative to the main peak using gradient elution and UV detection. |
| Residual Solvents | GC-FID | Detection and quantification of volatile organic solvents based on retention time and flame ionization response. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine reagent to determine trace water content based on stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) via plasma ionization and mass spectrometric detection. |
| Chloride Impurity | Ion Chromatography | Separation and conductivity-based quantification of chloride ions using anion-exchange column and suppressor system. |
| Residual Palladium | ICP-OES | Quantification of palladium catalyst residue by measuring atomic emission intensity at characteristic wavelengths after acid digestion. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating crystallinity and purity. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to assess chiral purity and absence of racemization. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity to calculate volume-based particle size distribution in dry or dispersed state. |
| pH of Aqueous Suspension | pH Meter | Measurement of hydrogen ion activity in a standardized suspension (e.g., 1% w/v in water) using calibrated glass electrode. |
| Microbial Contamination | Membrane Filtration | Enumeration of aerobic microorganisms by filtration, membrane transfer to culture media, and colony counting after incubation. |
Technical Specifications of 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 178-182°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
Safety Information of 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
Industrial 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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