2-chloro-5-cyanopyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 33252-28-7 |
| Product name | 2-chloro-5-cyanopyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeReagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-chloro-5-cyanopyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-chloro-5-cyanopyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-chloro-5-cyanopyridine
| Industry | Application | Process Description |
|---|---|---|
| Pesticides | Insecticide intermediate | Used in the synthesis of novel neonicotinoid insecticides, such as thiamethoxam |
| Pharmaceuticals | Drug synthesis intermediate | Serves as a key intermediate in the synthesis of antidepressants and antihistamines |
| Pharmaceuticals | Anticancer drug research | Applied in the synthesis of certain kinase inhibitors for cancer therapy research |
| Fine Chemicals | Functional material synthesis | Used as an organic synthesis intermediate in the preparation of optoelectronic materials |
| Research & Development | Chemical probe synthesis | Employed in synthesizing bioactive molecules and chemical probes for life science research |
| Pesticides | Fungicide synthesis | Serves as a structural modification intermediate for certain triazole fungicides |
Manufacturing Quality Control of 2-chloro-5-cyanopyridine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Related Substances (Impurities) | HPLC-UV or GC-FID | Separation and quantification of structurally related impurities (e.g., 2-chloropyridine, 5-cyanopyridine, dichloro analogs) using gradient HPLC or capillary GC with calibrated response factors. |
| Residual Solvents | GC-FID or GC-MS | Headspace GC analysis with flame ionization or mass spectrometric detection to quantify residual solvents (e.g., acetonitrile, dichloromethane, toluene) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with water in anhydrous methanol-based medium. |
| Heavy Metals (Total) | ICP-MS or ICP-OES | Digestion followed by elemental quantification of Pb, Cd, Hg, As, and other regulated metals using inductively coupled plasma mass spectrometry or optical emission spectroscopy. |
| Chloride Ion (Inorganic Chloride) | Ion Chromatography (IC) or Potentiometric Titration | Separation and quantification of Cl⁻ by IC with conductivity detection, or direct titration with AgNO₃ using potentiometric endpoint detection. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid transition temperature range using calibrated digital apparatus per USP <741>. |
| Appearance & Color | Visual Inspection / Hazen (APHA) Color Scale | Subjective visual assessment of crystallinity and color intensity compared against platinum-cobalt standards. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Analysis | High-temperature incineration of sample followed by weighing of non-volatile inorganic residue after sulfuric acid treatment. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using Mie theory to determine volume-based particle size distribution (D10, D50, D90). |
Technical Specifications of 2-chloro-5-cyanopyridine
| Test Item | Specification |
|---|---|
| Appearance | Brown solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 52–56°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-chloro-5-cyanopyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-chloro-5-cyanopyridine
Packaging of 2-chloro-5-cyanopyridine
Industrial 2-chloro-5-cyanopyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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