2-Hydroxy-5-trifluoromethylpyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 33252-63-0 |
| Product name | 2-Hydroxy-5-trifluoromethylpyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Hydroxy-5-trifluoromethylpyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Hydroxy-5-trifluoromethylpyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Hydroxy-5-trifluoromethylpyridine
| Industry | Application | Process |
|---|---|---|
| Pesticides | Key intermediate for novel insecticides and acaricides, used in synthesizing trifluoromethylpyridine active ingredients (e.g., analogues of flupyradifurone) | Forms C–N or C–C bonds via palladium-catalyzed cross-coupling with haloarenes or heterocyclic compounds; or reacts with acid chlorides/isocyanates to prepare amide derivatives |
| Pharmaceuticals | Structural building block for anticancer, anti-inflammatory, and central nervous system drugs, used to construct candidate molecules containing a trifluoromethylpyridine scaffold | Participates in late-stage drug molecule modifications, including nucleophilic substitution, reductive amination, Suzuki coupling, or Buchwald-Hartwig coupling |
| Materials Science | Monomer for functional electron-transport layer (ETL) materials in organic light-emitting diodes (OLEDs) | Introduced into conjugated polymer backbones—or used as a small-molecule ETL dopant—via lithiation-borylation or direct halogenation followed by Suzuki coupling |
Manufacturing Quality Control of 2-Hydroxy-5-trifluoromethylpyridine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at ~254 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification via retention time matching and/or spiked standards. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., methanol, acetone, ethyl acetate) based on calibrated response factors. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine generated electrochemically to react stoichiometrically with water in the sample. |
| Heavy Metals | ICP-MS | Quantitative determination of trace metals (e.g., Pb, Cd, Hg, As) after acid digestion, using mass spectrometry for element-specific detection at sub-ppt levels. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride anion using suppressed conductivity detection after aqueous extraction. |
| Sulfated Ash | Gravimetric Analysis | Incineration at 600-700 C followed by weighing of non-volatile inorganic residue after treatment with sulfuric acid. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid-to-liquid phase transition occurs, using calibrated capillary method per USP <741>. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of neat substance under controlled white light against defined standards (e.g., white crystalline powder). |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a saturated aqueous suspension (1:10 w/v) using calibrated pH electrode per EP 2.2.3. |
| Residue on Ignition | Gravimetric Analysis | Weighing of inorganic residue after ignition at 700-800 C, following USP <281> for non-volatile residue assessment. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light passing through a solution in a standardized cell, indicating chiral purity if applicable. |
Technical Specifications of 2-Hydroxy-5-trifluoromethylpyridine
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 68–72°C |
| Identification (NMR) | Conforms to reference standard |
| Identification (IR) | Conforms to reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Hydroxy-5-trifluoromethylpyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Hydroxy-5-trifluoromethylpyridine
Safety Information of 2-Hydroxy-5-trifluoromethylpyridine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2-Hydroxy-5-trifluoromethylpyridine
Industrial 2-Hydroxy-5-trifluoromethylpyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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