(R)-3-Piperidinamine dihydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 334618-23-4 |
| Product name | (R)-3-Piperidinamine dihydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-3-Piperidinamine dihydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-3-Piperidinamine dihydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-3-Piperidinamine dihydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a chiral intermediate in the synthesis of antiviral agents (e.g., HIV protease inhibitors) and neuropsychiatric drugs | (R)-3-Aminopiperidine is prepared via asymmetric synthesis or chiral resolution, followed by hydrochloride salt formation and purification |
| Pharmaceuticals | Employed to construct piperidine-containing active pharmaceutical ingredients (APIs), such as 5-HT3 receptor antagonists | Serves as a key chiral building block in condensation, reduction, or alkylation reactions; the final API is isolated as a crystalline salt after multistep synthesis |
| Chemical R&D | Utilized as a chiral ligand or catalyst precursor in organic catalytic reactions | Purified material is applied in chiral-induction processes, including asymmetric hydrogenation and Mannich reactions |
Manufacturing Quality Control of (R)-3-Piperidinamine dihydrochloride
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual inspection, physical observation | Observe the color, state (e.g., white to off-white crystalline powder), and odor of the sample. |
| Identification | Infrared Spectroscopy (IR) | Compare the infrared absorption spectrum with a standard spectrum to confirm the consistency of functional group characteristic peaks. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Determine the chemical shift and coupling constants of hydrogen atoms to verify structural consistency and (R)-configuration. | |
| Specific Rotation Determination | Measure the specific rotation using a polarimeter under specified conditions to confirm optical purity and (R)-configuration. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use reversed-phase HPLC to separate the main component with an appropriate mobile phase (e.g., phosphate buffer-acetonitrile system), and quantify using external standard method or area normalization. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use the same conditions as content determination or gradient elution program to detect and quantify process impurities, degradation products, etc. Typically set limits for individual impurities and total impurities. |
| Enantiomeric Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Separate (R) and (S) enantiomers using a chiral stationary phase column, and assess enantiomeric excess (e.e. value) to ensure optical purity. |
| Moisture | Karl Fischer Titration (Karl Fischer) | Determine the moisture content using volumetric or coulometric methods to control the level of crystalline water or adsorbed water. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection to detect residual organic solvents (e.g., methanol, ethanol, dichloromethane) from synthesis or purification processes. |
| Ignited Residue / Sulfated Ash | Weight Method | Quantify the inorganic residue after high-temperature ignition, to assess the total amount of inorganic impurities. |
| pH Value | pH Meter Measurement | Prepare a solution of certain concentration and measure its pH value using a calibrated pH meter, reflecting the dissociation characteristics of the hydrochloride salt. |
| Chloride Content | Ion Chromatography (IC) or Argentometry | Quantitatively determine the Cl⁻ ion content to verify whether it meets the theoretical chloride content of the dihydrochloride (approximately 2 mol HCl per mol API). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect harmful elements such as lead, cadmium, mercury, and arsenic to ensure compliance with pharmacopoeia or ICH Q3D element impurity limits. |
Technical Specifications of (R)-3-Piperidinamine dihydrochloride
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (by NMR) |
| Optical Rotation | -3.0 to -1.0 deg (c=1, in H2O) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-3-Piperidinamine dihydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-3-Piperidinamine dihydrochloride
Safety Information of (R)-3-Piperidinamine dihydrochloride
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of (R)-3-Piperidinamine dihydrochloride
Industrial (R)-3-Piperidinamine dihydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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