4-Chloro-D-phenylalanine methyl ester hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 33965-47-8 |
| Product name | 4-Chloro-D-phenylalanine methyl ester hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Chloro-D-phenylalanine methyl ester hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Chloro-D-phenylalanine methyl ester hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Chloro-D-phenylalanine methyl ester hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used as a precursor in the synthesis of the antineoplastic agent L-phenylalanine mustard (melphalan) | Hydrolyzed to 4-chloro-L-phenylalanine under alkaline conditions, followed by acylation, alkylation, and other sequential reactions to produce melphalan |
| Pharmaceutical Intermediates | Serves as a chiral building block for structural modification of proteasome inhibitor drugs | Specific side chains are introduced via transesterification or aminolysis to construct peptide derivatives containing the chlorophenylalanine motif |
| Research Reagents | Used to study the effects of chlorinated amino acids on protein folding and enzyme activity | Incorporated as a non-canonical amino acid into model proteins in cell-free translation systems or site-directed mutagenesis experiments |
Manufacturing Quality Control of 4-Chloro-D-phenylalanine methyl ester hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 220 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess measured using a chiral stationary phase and UV detection, resolving D- and L-isomers based on differential retention. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., methanol, dichloromethane) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine and sulfur dioxide in pyridine/methanol medium to quantify trace water content. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after acid digestion and plasma excitation. |
| Chloride Ion Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode to determine chloride concentration based on potential inflection point. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., des-chloro, hydrolyzed, or diastereomeric analogs) using gradient HPLC-UV. |
| Residue on Ignition | Gravimetric Analysis | Measurement of non-volatile inorganic residue after high-temperature ashing at 700-800 C and weighing. |
| pH (1% aqueous solution) | pH Meter Measurement | Direct potentiometric measurement of hydrogen ion activity in a standardized aqueous solution. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range over which solid transitions to liquid, indicating purity and identity. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral molecules in solution at specified concentration and wavelength. |
Technical Specifications of 4-Chloro-D-phenylalanine methyl ester hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Optical Rotation | +15.0 to +17.0° (c=1, in 1M HCl) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Chloro-D-phenylalanine methyl ester hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Chloro-D-phenylalanine methyl ester hydrochloride
Safety Information of 4-Chloro-D-phenylalanine methyl ester hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Chloro-D-phenylalanine methyl ester hydrochloride
Industrial 4-Chloro-D-phenylalanine methyl ester hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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