Propafenone Hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 34183-22-7 |
| Product name | Propafenone Hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Propafenone Hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Propafenone Hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Propafenone Hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Antiarrhythmic agent for treating supraventricular and ventricular arrhythmias | Formulated as an active pharmaceutical ingredient (API) into tablets or injectables for oral or intravenous administration |
| Pharmaceutical R&D | Pharmacological research tool for studying sodium channel blockade mechanisms | Used as a selective sodium channel blocker in in vitro or in vivo experiments |
| Pharmaceutical Manufacturing | Drug intermediate or reference standard | Employed in the synthesis of other antiarrhythmic compounds or as a reference material in analytical testing |
Manufacturing Quality Control of Propafenone Hydrochloride
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification Test | Infrared Spectroscopy (IR) | Determines the infrared absorption spectrum of the sample and compares it with a reference spectrum to confirm consistency of molecular structural features and functional groups. |
| High-Performance Liquid Chromatography (HPLC) | Identifies the substance based on retention time matching that of the reference standard; often used in conjunction with other tests. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 column with a specific mobile phase (e.g., methanol-phosphate buffer) under isocratic or gradient elution conditions, detected by UV detector (typically around 254 nm), and quantifies the main component using external standard method. |
| Related Substances (Impurity Testing) | High-Performance Liquid Chromatography (HPLC) | Employs a high-sensitivity HPLC system with optimized chromatographic conditions to separate the main peak from potential impurities (e.g., degradation products, synthetic intermediates). Impurity levels are controlled using area normalization or self-reference methods. |
| Residual Solvents | Gas Chromatography (GC) | Utilizes headspace injection or direct injection with capillary columns and FID detection to test for residual organic solvents (e.g., methanol, ethanol, dichloromethane) as specified in pharmacopoeial guidelines. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Constant-Pressure Drying Method | Dries the sample at a specified temperature (e.g., 105°C) until constant weight is achieved, measuring mass loss to assess moisture and volatile substance content. |
| Residue on Ignition | Gravimetric Method | After high-temperature ignition, the residue of inorganic matter is weighed to control total inorganic impurity levels. |
| pH Value | pH Meter Measurement | Prepares an aqueous solution at a defined concentration and measures its acidity or alkalinity using a calibrated pH meter to ensure compliance with pharmacopoeial specifications. |
| Heavy Metals | Thioacetamide Method or Atomic Absorption Spectroscopy (AAS) | Detects excessive levels of heavy metals such as lead, cadmium, mercury, and arsenic through colorimetric reactions or instrumental analysis. |
| Polymorphism (if applicable) | X-Ray Powder Diffraction (XRPD) or Differential Scanning Calorimetry (DSC) | Used to confirm the presence of polymorphic forms in active pharmaceutical ingredients, ensuring consistent crystal form that impacts formulation stability and dissolution behavior. |
Technical Specifications of Propafenone Hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 160–164°C |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Propafenone Hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Propafenone Hydrochloride
Packaging of Propafenone Hydrochloride
Industrial Propafenone Hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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