N-Methyl-L-prolinol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 34381-71-0 |
| Product name | N-Methyl-L-prolinol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Methyl-L-prolinol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Methyl-L-prolinol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Methyl-L-prolinol
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral synthetic intermediate | Used as a chiral auxiliary or ligand in asymmetric synthesis to construct drug molecules with defined stereochemistry |
| Organic synthesis | Organic catalyst | Applied as a small-molecule organic catalyst in reactions such as aldol condensation and Michael addition |
| Agrochemical chemistry | Synthetic intermediate | Employed as a chiral intermediate in the synthesis of nitrogen-containing heterocyclic agrochemicals to enhance biological activity and selectivity |
| Materials science | Functionalization reagent | Utilized in the preparation of functional polymers or ligand materials with tailored structures |
Manufacturing Quality Control of N-Methyl-L-prolinol
| Test Item | Common Test Methods | Method Summary |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection, Physical Property Testing | Observe sample color and state (typically white to off-white crystalline powder), and determine melting point range (literature value approximately 105–110°C) to assess purity. |
| Assay (Main Component) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with water-acetonitrile or methanol as the mobile phase, and UV detection at 210–220 nm. Quantify the main component using external or internal standard methods, typically requiring ≥98.0%. |
| Related Substances (Impurity Profile) | HPLC with Gradient Elution | Employ gradient elution HPLC to separate potential structurally related impurities (e.g., N-methyl-D-prolinol, unreacted proline derivatives, demethylated products). Detection limit is typically 0.1%, reporting threshold 0.05%. |
| Residual Solvents | Gas Chromatography (GC) | Use DB-624 or HP-INNOWAX column with headspace injection to detect ICH Q3C-listed solvents such as methanol, ethanol, dichloromethane, and ethyl acetate, ensuring compliance with specified limits. |
| Water Content | Karl Fischer Titration | Determine moisture content using volumetric or coulometric Karl Fischer titration. Typically controlled at ≤0.5% (w/w) to ensure stability and solubility. |
| Optical Rotation | Polarimetry | Prepare a solution of specified concentration (e.g., 10 mg/mL) in water and measure specific optical rotation [α]₂₀ᴰ at 20°C. N-Methyl-L-prolinol should exhibit levorotatory (negative) rotation, with a typical range of -20° to -25°, confirming stereochemical configuration. |
| pH (Acidity/Alkalinity) | pH Meter Measurement | Prepare a 1% aqueous solution and measure pH. Typically controlled within 5.0–7.5 to avoid instability caused by acidic or basic impurities. |
| Chlorides, Sulfates | Ion Chromatography or Colorimetric Methods | Determine chloride and sulfate ion content using ion chromatography or pharmacopoeial colorimetric tests (e.g., reaction of chlorides with silver nitrate). Limits are set in ppm (e.g., Cl⁻ ≤100 ppm). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Digest the sample and measure levels of heavy metals such as lead, cadmium, mercury, and arsenic. Must comply with ICH Q3D or pharmacopoeial limits (e.g., Pb ≤10 ppm). |
| Particle Size Distribution (if applicable) | Laser Diffraction or Microscopy | If used as a powdered active pharmaceutical ingredient, measure particle size distribution (e.g., D50), ensuring flowability and dissolution performance meet process requirements (e.g., D90 < 100 μm). |
| Microbial Limits | Pharmacopoeial Microbiological Testing | Test for total aerobic microbial count, molds and yeasts, and presence of *Escherichia coli*. Must comply with non-sterile API standards (e.g., ≤10³ CFU/g). |
Technical Specifications of N-Methyl-L-prolinol
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -51.0 to -48.0 deg (c=1, in methanol) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Methyl-L-prolinol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Methyl-L-prolinol
Packaging of N-Methyl-L-prolinol
Industrial N-Methyl-L-prolinol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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