3-Acetylpyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 350-03-8 |
| Product name | 3-Acetylpyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3-Acetylpyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3-Acetylpyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3-Acetylpyridine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of anti-tuberculosis drugs (e.g., isoniazid, ethionamide) | Serves as a chemical raw material for synthesizing active pharmaceutical ingredients via chemical reaction |
| Pharmaceuticals | Intermediate in the synthesis of antiepileptic and other central nervous system drugs (e.g., brivaracetam) | Used as a chemical raw material in drug synthesis reactions |
| Agrochemicals | Intermediate in the synthesis of plant growth regulators | Prepared via chemical synthesis |
| Flavors & Fragrances | Used in formulating food and tobacco flavorings | Added during flavor compounding to enhance nutty, roasted, or tobacco-like notes |
| Chemical Synthesis | Organic synthesis raw material for preparing pyridine derivatives | Functions as an intermediate in various organic chemical reactions |
Manufacturing Quality Control of 3-Acetylpyridine
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Active Ingredient Content) | High-Performance Liquid Chromatography (HPLC) | Using a C18 column with gradient elution of water-acetonitrile or methanol as the mobile phase, detection by UV detector (254 nm), and quantification via external or internal standard method. Offers high sensitivity and excellent selectivity. |
| Impurity Profile Analysis | High-Performance Liquid Chromatography (HPLC) | Employing a gradient elution program to detect potential impurities such as unreacted starting materials (e.g., 3-pyridinemethanol, 3-pyridinecarboxylic acid), by-products (e.g., diacetylated derivatives), and degradation products; calculates total impurity levels and individual impurity contents. |
| Moisture Content | Karl Fischer Titration | Utilizes an iodine–sulfur dioxide–pyridine–methanol system that reacts quantitatively with water. Water content is determined precisely by coulometric or volumetric methods, suitable for trace moisture determination in organic solvents (typically required ≤0.5%). |
| Melting Point | Melting Point Apparatus | Determines the melting temperature range using a digital melting point apparatus. The theoretical melting point of 3-acetylpyridine is approximately 45–48 °C, used for preliminary assessment of purity and crystal form consistency. |
| Odor / Appearance | Visual and Sensory Evaluation | Sample should be a colorless to slightly yellow liquid with characteristic pyridine-like odor, free from visible particles or precipitates, meeting pharmacopoeial or internal quality specifications. |
| Residual Solvents | Gas Chromatography (GC) | Headspace or direct injection method using DB-624 or HP-INNOWAX columns with FID detection to determine residual organic solvents such as ethanol, acetone, and ethyl acetate, in compliance with ICH Q3C guidelines. |
| Content Uniformity (in Formulations) | HPLC or UV Spectrophotometry | If used in formulations (e.g., as a pharmaceutical intermediate), HPLC can be employed to assess content uniformity of 3-acetylpyridine; alternatively, UV spectrophotometry at specific wavelengths (e.g., 260–270 nm) may be used with interference correction. |
| pH / Acidity-Basicity | pH Meter Method | Dissolve sample in water or buffer solution and measure pH value (typically neutral to weakly acidic) to ensure absence of strong acidic or basic contaminants. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Sample is digested according to pharmacopoeial methods (e.g., USP <231> or EP 2.5.11), followed by determination of heavy metals such as lead, cadmium, mercury, and arsenic. Must meet specified limits (typically ≤10 ppm). |
Technical Specifications of 3-Acetylpyridine
| Test Item | Specification |
|---|---|
| Appearance | Colorless to yellow clear liquid |
| Purity | >=98.5% (GC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.525–1.535 |
| Relative Density (20°C/4°C) | 1.015–1.025 g/cm³ |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3-Acetylpyridine
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NMR Spectra of 3-Acetylpyridine
Packaging of 3-Acetylpyridine
Industrial 3-Acetylpyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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