BIOTIN-NHS Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 35013-72-0 |
| Product name | BIOTIN-NHS |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for BIOTIN-NHS
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk BIOTIN-NHS Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of BIOTIN-NHS
| Industry | Application | Process |
|---|---|---|
| Biotechnology | Biotinylation of proteins, antibodies, or nucleic acids | Reacting (+) biotin-N-hydroxysuccinimide ester with primary amines (e.g., lysine residues) on target molecules under mild alkaline conditions (pH 7–9) to form stable amide bonds for covalent conjugation |
| Diagnostics | Probe labeling for immunoassays (e.g., ELISA, Western blot) | Labeling primary or secondary antibodies to amplify detection signals via the high-affinity streptavidin–biotin system |
| Pharmaceutical R&D | Target protein enrichment and identification | Labeling proteins in cell lysates for chemical proteomics, followed by affinity purification using streptavidin-coated magnetic beads |
| Molecular Biology | Labeling nucleic acid probes | Reacting with amino-modified oligonucleotides to prepare biotinylated probes for hybridization assays or capture-based sequencing |
| Materials Science | Functional surface modification (e.g., biochips) | Conjugating the reagent to amino-functionalized solid-phase supports to construct biointerfaces capable of capturing streptavidin-fusion proteins |
Manufacturing Quality Control of BIOTIN-NHS
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification via UV absorbance at 200 nm using a C18 column and calibrated standard curve. |
| Related Substances | HPLC-UV | Separation and detection of structurally similar impurities using gradient elution and UV detection. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents based on retention time and flame ionization response. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine reagent to determine water content by stoichiometric reaction. |
| Residual N-Hydroxysuccinimide | HPLC-UV | Separation and UV quantification of NHS impurity using reverse-phase chromatography. |
| Heavy Metals | ICP-OES | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg) after acid digestion and plasma excitation. |
| Chloride Content | Ion Chromatography | Anion exchange separation followed by conductivity detection of chloride ions. |
| pH of Solution (1% w/v) | Potentiometric pH Measurement | Measurement of hydrogen ion activity in aqueous suspension using calibrated pH electrode. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of foreign particles under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid using capillary tube method. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light induced by chiral centers in solution. |
| Microbial Contamination | Membrane Filtration and Plate Count | Enumeration of viable aerobic microorganisms after filtration and agar plate incubation. |
Technical Specifications of BIOTIN-NHS
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Optical Rotation | +52.0 to +55.0 deg (c=1, in water) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of BIOTIN-NHS
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of BIOTIN-NHS
Packaging of BIOTIN-NHS
Industrial BIOTIN-NHS Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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