N-ETHYL-4-HYDROXYPIPERIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 3518-83-0 |
| Product name | N-ETHYL-4-HYDROXYPIPERIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-ETHYL-4-HYDROXYPIPERIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-ETHYL-4-HYDROXYPIPERIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-ETHYL-4-HYDROXYPIPERIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of opioid analgesics (e.g., oxycodone, oxymorphone) | Introduced as a piperidine ring substituent during drug molecule construction; the N-alkylation site and C-4 hydroxyl group participate in subsequent condensation and oxidation steps |
| Pharmaceuticals | Structural building block for selective 5-HT2A receptor antagonists and psychiatric drug candidates | Hydroxyl reactivity modulated via protection/deprotection strategies to construct chiral piperidine-containing active molecules |
| Fine Chemicals | Precursor for high-performance catalyst ligands | Hydroxyl and ethyl groups jointly tune nitrogen electron density; further derivatized to produce N,O-bidentate ligands for transition metal catalytic systems |
Manufacturing Quality Control of N-ETHYL-4-HYDROXYPIPERIDINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Gas Chromatography (GC) with FID detection | Quantitative determination based on peak area comparison against a certified reference standard using a non-polar capillary column. |
| Related Substances | High-Performance Liquid Chromatography (HPLC) with UV detection | Separation and quantification of impurities using reversed-phase C18 column and UV absorbance at 210 nm. |
| Water Content | Karl Fischer Titration (coulometric mode) | Electrochemical titration where iodine generated in situ reacts stoichiometrically with water in the sample. |
| Residue on Ignition | Gravimetric analysis after high-temperature ashing | Mass of non-volatile inorganic residue measured after incineration at 700-800 C in a muffle furnace. |
| Heavy Metals | ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometry) | Multi-element quantification of metal impurities by measuring characteristic atomic emission lines after acid digestion. |
| Chloride Content | Potentiometric titration with silver nitrate | Titration based on formation of insoluble silver chloride, detected by silver-ion selective electrode. |
| pH of Aqueous Solution | Potentiometric pH measurement | Determination of hydrogen ion activity in a 1% w/v aqueous solution using calibrated glass electrode. |
| Appearance | Visual inspection in transmitted light | Assessment of physical state, color, and clarity against water-white standard in a Nessler tube under controlled lighting. |
| Melting Point | Capillary melting point apparatus | Thermal transition temperature range determined by observing solid-to-liquid phase change under controlled heating rate. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light caused by chiral molecules in solution at specified concentration and wavelength. |
| Residual Solvents | Headspace Gas Chromatography (HS-GC) with FID | Quantitative analysis of volatile organic solvents via equilibrium partitioning into headspace followed by GC separation. |
| Sulfated Ash | Gravimetric analysis after sulfuric acid treatment | Mass of residue remaining after wet-ashing with H2SO4 and subsequent incineration at 600 C. |
Technical Specifications of N-ETHYL-4-HYDROXYPIPERIDINE
| Test Item | Specification |
|---|---|
| Appearance | Yellow liquid |
| Purity | >=98.5% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | -20 to -15°C |
| Refractive Index (n20/D) | 1.465–1.475 |
| Odor | Characteristic amine-like odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-ETHYL-4-HYDROXYPIPERIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-ETHYL-4-HYDROXYPIPERIDINE
Packaging of N-ETHYL-4-HYDROXYPIPERIDINE
Industrial N-ETHYL-4-HYDROXYPIPERIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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