Ethyl 4,4-difluoro-3-oxobutanoate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 352-24-9 |
| Product name | Ethyl 4,4-difluoro-3-oxobutanoate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Ethyl 4,4-difluoro-3-oxobutanoate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Ethyl 4,4-difluoro-3-oxobutanoate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Ethyl 4,4-difluoro-3-oxobutanoate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of fluorinated quinolone antibiotic intermediates | Used as a key intermediate to construct fluorinated ring systems; participates in condensation and cyclization reactions for antibacterial drug synthesis |
| Pesticides | Synthesis of fluorinated insecticide or herbicide intermediates | Applied in the preparation of biologically active fluorinated heterocyclic compounds; fluorine is introduced into target molecules via nucleophilic substitution or coupling reactions |
| Organic Synthesis | Reagent for synthesizing fluorinated organic compounds | Employed as a β-keto ester-based fluorinated building block in Claisen condensations, alkylations, and reductions |
Manufacturing Quality Control of Ethyl 4,4-difluoro-3-oxobutanoate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Gas Chromatography (GC) with FID detection | Quantitative determination based on peak area comparison against a certified reference standard using a calibrated column and detector. |
| Water Content | Karl Fischer Titration | Electrochemical titration where iodine reacts stoichiometrically with water in a methanol-based solvent system. |
| Residual Solvents | Gas Chromatography (GC) with Headspace sampling | Separation and quantification of volatile organic impurities using headspace equilibrium and GC-FID or GC-MS detection. |
| Acidity (as HCl) | Acid-Base Titration with NaOH | Neutralization of acidic impurities using standardized sodium hydroxide solution and potentiometric or indicator endpoint detection. |
| Color | Visual Comparison to APHA Scale | Subjective assessment of sample color intensity by matching against platinum-cobalt standard solutions under controlled lighting. |
| Density | Digital Density Meter | Measurement of mass per unit volume at specified temperature using oscillating U-tube principle. |
| Refractive Index | Digital Refractometer | Determination of light bending angle at air-sample interface to infer purity and composition. |
| Chloride Impurity | Ion Chromatography (IC) | Separation and quantification of chloride anions using ion-exchange column and conductivity detection. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element detection via plasma ionization and mass spectrometric analysis after acid digestion and dilution. |
| Residue on Ignition | Gravimetric Analysis | Weighing of non-volatile inorganic residue remaining after high-temperature ashing of the sample. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral compounds in solution. |
| Related Substances | HPLC with UV Detection | Separation and quantification of structurally similar impurities using reversed-phase chromatography and UV absorbance at 210 nm. |
Technical Specifications of Ethyl 4,4-difluoro-3-oxobutanoate
| Test Item | Specification |
|---|---|
| Appearance | Colorless to almost colorless clear liquid |
| Purity | >=98.5% (GC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.405–1.415 |
| Relative Density (20°C/25°C) | 1.140–1.160 g/cm³ |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Ethyl 4,4-difluoro-3-oxobutanoate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Ethyl 4,4-difluoro-3-oxobutanoate
Safety Information of Ethyl 4,4-difluoro-3-oxobutanoate
| Pictograms |   |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Ethyl 4,4-difluoro-3-oxobutanoate
Industrial Ethyl 4,4-difluoro-3-oxobutanoate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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