4-Hydroxy-6-methylpyrimidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 3524-87-6 |
| Product name | 4-Hydroxy-6-methylpyrimidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Hydroxy-6-methylpyrimidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Hydroxy-6-methylpyrimidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Hydroxy-6-methylpyrimidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of sulfonamide drugs (e.g., sulfamethazine, sulfamethoxypyridazine) | Serves as a key intermediate in condensation reactions |
| Agrochemicals | Synthesis of herbicides and insecticides | Reacts with other organic compounds to construct biologically active structures |
| Chemical Synthesis | Preparation of pyrimidine derivatives | Used for functionalization and construction of functional molecules |
| Analytical Chemistry | Organic synthesis standard or analytical reagent | Employed in qualitative or quantitative analysis |
Manufacturing Quality Control of 4-Hydroxy-6-methylpyrimidine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity Analysis | High-Performance Liquid Chromatography (HPLC) | Utilizes a C18 reversed-phase chromatographic column with a water-methanol or acetonitrile gradient elution system. The main component content is determined using a UV detector (254–280 nm), and purity is calculated via peak area normalization or external standard method. |
| Content Determination | HPLC External Standard Method | Prepares a series of standard solutions at known concentrations to establish a calibration curve. The content of 4-hydroxy-6-methylpyrimidine is calculated by correlating the sample peak area with the calibration curve. This method offers high precision and is suitable for active pharmaceutical ingredient (API) control. |
| Impurity Analysis | HPLC-MS (Liquid Chromatography-Mass Spectrometry) | Combines HPLC with a mass spectrometry detector to identify and quantify known or unknown impurities (e.g., degradation products, synthetic intermediates), providing molecular weight and structural information. |
| Melting Point Determination | Capillary Melting Point Apparatus | According to the Chinese Pharmacopoeia general chapter, the melting point range of the sample is measured (literature value: approximately 170–175°C) to preliminarily assess purity and crystalline form consistency. |
| Water Content Determination | Karl Fischer Titration (KF Method) | Quantifies trace water in the sample based on the reaction between iodine, sulfur dioxide, pyridine, and methanol. Used to control the impact of hygroscopicity on product stability. |
| Ultraviolet Absorption Characteristics | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Measures the maximum absorption wavelength (typically 260–280 nm) in ethanol or aqueous solution for qualitative confirmation and rapid quantitative analysis (requires a calibration curve). |
| Crystal Form Analysis | X-ray Powder Diffraction (XRPD) | Determines crystalline morphology based on characteristic diffraction peak positions and intensities to ensure batch-to-batch crystal form consistency and avoid potential impacts on solubility and stability due to polymorphic differences. |
| Inorganic Impurities (e.g., Chlorides, Sulfates) | Ion Chromatography (IC) or Colorimetric Method | Uses ion chromatography to separate and detect inorganic anions such as chloride and sulfate ions, or employs classical colorimetric methods (e.g., silver chloride precipitation) to control residual inorganic impurities. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, heavy metals such as lead, cadmium, and mercury are quantified using AAS or inductively coupled plasma mass spectrometry (ICP-MS), in compliance with ICH Q3D guidelines. |
| Residual Solvents | Gas Chromatography (GC) | Employs headspace or direct injection with a flame ionization detector (FID) to measure residual organic solvents (e.g., methanol, ethanol, acetone), in accordance with ICH Q3C standards. |
Technical Specifications of 4-Hydroxy-6-methylpyrimidine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 178–182°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Hydroxy-6-methylpyrimidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Hydroxy-6-methylpyrimidine
Packaging of 4-Hydroxy-6-methylpyrimidine
Industrial 4-Hydroxy-6-methylpyrimidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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