Fmoc-Leu-OH Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 35661-60-0 |
| Product name | Fmoc-Leu-OH |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-Leu-OH
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-Leu-OH Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-Leu-OH
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Protected amino acid monomer for peptide synthesis | Used as an Fmoc-protected leucine building block for N-terminal α-amino protection in solid-phase peptide synthesis (SPPS), enabling synthesis of therapeutic peptides or protein fragments |
| Biotechnology | Peptide-based drug and vaccine development | Applied in stepwise coupling via the Fmoc/tBu strategy, with Fmoc deprotection using piperidine to enable sequence-controlled peptide chain elongation |
| Research Reagents | Organic synthesis and chemical biology research | Used as a reference standard or intermediate in enzyme substrate design, protein mimetic synthesis, and structure–activity relationship (SAR) studies |
Manufacturing Quality Control of Fmoc-Leu-OH
| Test Item | Common Test Methods | Method Summary |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, physical state, presence of caking, and visible impurities under natural or standard lighting conditions. |
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Using a reversed-phase column (e.g., C18) and a UV detector (typically at around 265 nm), qualitative analysis is performed based on retention time, and quantitative analysis of Fmoc-L-leucine content is conducted using peak area normalization or external standard method. |
| Chiral Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Separation of L- and D-form isomers using a chiral stationary phase column, evaluating enantiomeric excess (ee value) to ensure no residual D-isomer. |
| Moisture Content | Karl Fischer Titration | Determine the content of crystalline or adsorbed water by the quantitative reaction of iodine with sulfur dioxide in a methanol/water system. |
| Residual Solvents | Gas Chromatography (GC) | Detect possible residual solvents (e.g., DMF, toluene, ethyl acetate) from the manufacturing process using headspace or solution injection GC, meeting ICH limit requirements. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Determine the content of toxic elements such as lead, mercury, cadmium, and arsenic after sample digestion, ensuring compliance with pharmacopoeia or customer-specified limits. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Method | Carbonize the sample at high temperature, treat with sulfuric acid, then ignite until constant weight is achieved. The residue is weighed to assess the total inorganic impurities. |
| pH Value | pH Meter Measurement | Prepare a 1% (w/v) aqueous solution of Fmoc-L-leucine and measure the pH using a calibrated pH meter. |
| Melting Point | Melting Point Apparatus | Determine the initial and final melting temperatures using capillary method or an automatic melting point instrument for identification and assessment of crystalline purity. |
| Microbial Limits | Microbial Limit Testing | Perform tests according to pharmacopoeia methods, including total aerobic microbial count, total mold and yeast count, and specified microorganisms (e.g., Escherichia coli), applicable for pharmaceutical-grade products. |
Technical Specifications of Fmoc-Leu-OH
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 70–74°C |
| Optical Rotation | -26.0 to -24.0° (c=1, in DMF) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-Leu-OH
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-Leu-OH
Packaging of Fmoc-Leu-OH
Industrial Fmoc-Leu-OH Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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