(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 361440-67-7 |
| Product name | (1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 361440-67-7
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 361440-67-7 Supplier from China
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Industrial Applications of 361440-67-7
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral intermediate for synthesizing targeted protein degraders (e.g., PROTACs) and neurokinin-1 (NK1) receptor antagonists containing a bicyclo[3.1.0]hexane scaffold | Used in multi-step coupling reactions following asymmetric synthesis, chiral resolution, or enzymatic modification; final product assembly typically involves deprotection, amidation, or Ullmann coupling |
| Organic Synthesis | Key building block for constructing rigid, three-dimensional chiral azabicyclic structures to design conformationally constrained bioactive molecules | Employed as a chiral auxiliary in Diels–Alder reactions, 1,3-dipolar cycloadditions, or transition metal-catalyzed C–N bond formation; the tert-butyl ester group enables subsequent selective removal and functional group transformation |
Manufacturing Quality Control of 361440-67-7
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210-220 nm based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient HPLC-UV; identification supported by retention time matching and spiked controls. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., toluene, THF, ethyl acetate) by headspace GC with flame ionization detection using calibrated standards. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generation in pyridine-free reagent system. |
| Optical Rotation | [alpha]D Measurement | Measures specific optical rotation at 20 C using sodium D-line (589 nm) to confirm chiral integrity and enantiomeric purity. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Pd) after acid digestion using inductively coupled plasma mass spectrometry with isotope dilution. |
| Residual Palladium | ICP-MS | Specific quantification of Pd catalyst residue post-coupling steps using ICP-MS with Pd-105 or Pd-106 isotopic monitoring. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction and filtration. |
| Residual TFA | GC-FID | Detects trifluoroacetic acid by direct injection GC-FID with polar column and temperature programming. |
| Particle Size Distribution | Laser Diffraction | Measures dry powder particle size distribution using Mie theory-based light scattering analysis under controlled dispersion. |
| Bulk Density | ASTM D1895 | Determines mass per unit volume of freely settled powder using standardized graduated cylinder and weight measurement. |
| Microbial Limits | Membrane Filtration | Quantifies aerobic microorganisms and detects specified pathogens (e.g., E. coli, S. aureus) using selective agar media and incubation per USP <61>. |
Technical Specifications of 361440-67-7
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142°C - 147°C |
| Optical Rotation | +18.5° to +20.5° (c=1, in CHCl3) |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 361440-67-7
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 361440-67-7
Packaging of 361440-67-7
Industrial 361440-67-7 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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