China Factory Direct
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| CAS number | 365-24-2 |
| Product name | 4,4'-Difluorobenzhydrol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeElectronic GradeMaterial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Polymers | Monomer intermediate for synthesizing high-performance engineering plastics such as polyaryletherketones (e.g., PEEK, PEKK) | Undergoes nucleophilic substitution and condensation with bisphenols, or serves as a diphenol precursor in high-temperature polymerization |
| Pharmaceutical Chemicals | Fluorinated pharmaceutical intermediate, serving as a structural unit in anti-inflammatory and antitumor compounds | Modified via hydroxyl functional groups to participate in esterification, etherification, or coupling reactions for drug scaffold construction |
| Electronic Chemicals | Precursor for high-performance insulating materials and liquid crystal polymers | Condenses with 4,4'-difluorodiphenyl sulfone or 4,4'-difluorobenzophenone to form thermally stable aromatic polymers |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 220 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification based on retention time matching and threshold limits per ICH Q3A. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, toluene) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and others after acid digestion, based on atomic emission intensities at characteristic wavelengths. |
| Chloride Impurity | Ion Chromatography | Separation and conductivity detection of chloride ions in aqueous extract; quantified against sodium chloride calibration curve. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, measured using calibrated capillary apparatus per USP <741>. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of sample against water-white standard under controlled white light and specified viewing conditions. |
| Acid Value | Acid-Base Titration | Titration with standardized KOH solution to neutralize acidic impurities; calculated as mg KOH per g sample. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue remaining after high-temperature ashing (700-800 C) to determine inorganic non-volatile content. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion using laser scattering to determine volume-based particle size distribution (D10, D50, D90). |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light passed through a solution to assess chiral purity and absence of racemization. |
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 124–128°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Heavy Metals | <=10 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.