4-Chloro-2-picoline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 3678-63-5 |
| Product name | 4-Chloro-2-picoline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Chloro-2-picoline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Chloro-2-picoline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Chloro-2-picoline
| Industry | Application | Process |
|---|---|---|
| Pesticides | Intermediate for synthesizing insecticides and herbicides | Used as a key intermediate in the synthesis of pesticide products such as forchlorfenuron and acetamiprid |
| Pharmaceuticals | Intermediate for drug synthesis | Applied in the preparation of biologically active nitrogen-containing heterocyclic drug molecules |
| Fine Chemicals | Organic synthesis raw material | Participates in coupling and substitution reactions to construct complex organic molecular structures |
Manufacturing Quality Control of 4-Chloro-2-picoline
| Test Item | Common Testing Method | Method Summary |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Uses a C18 column with methanol-water or acetonitrile-water as the mobile phase, and detects with a UV detector (usually at 254 nm). Quantification is done by external standard or internal standard method, providing high resolution and accuracy. |
| Impurity Analysis (Organic Impurities) | High-Performance Liquid Chromatography (HPLC) | A gradient elution program is used to separate the main component from possible structural analogs (e.g., unreacted raw materials, by-products, degradation products). The detection limit can reach ppm level, complying with ICH Q3B guidelines. |
| Water Content | Karl Fischer Titration | Utilizes an iodine-sulfur dioxide-pyridine-methanol system that reacts quantitatively with water. Endpoint is determined electrochemically or visually. Suitable for trace moisture determination with precision down to 0.001%. |
| Residual Solvents | Gas Chromatography (GC) | Uses DB-624 or HP-INNOWAX capillary columns with FID detector. Quantifies residual solvents such as ethanol, acetone, DMF according to USP/EP methods, meeting ICH Q3C standards. |
| Melting Point | Melting Point Apparatus Method | Determines the melting temperature range using a digital melting point apparatus. Used for preliminary identification and purity assessment; typical melting point range is 45–48°C. |
| Appearance and Color | Visual Inspection + Colorimetry (Colorimetric Method) | Observes solid state (white to light yellow crystals), and evaluates yellowness index using a colorimeter or color chart, ensuring compliance with pharmacopoeial requirements on color. |
| Chlorine Content | Combustion Ion Chromatography / Oxygen Bomb Combustion + Ion Chromatography | The sample is combusted in an oxygen bomb to convert chlorine into chloride ions, which are then absorbed and analyzed by ion chromatography (IC) to determine Cl⁻ concentration. Used to verify whether the chlorine atom content matches theoretical values. |
| pH Value (Solution) | pH Meter Method | The sample is dissolved in water or buffer solution, and the pH value is measured using a calibrated pH meter to assess its acidity or alkalinity, useful for process control (typically neutral to slightly acidic). |
| Particle Size Distribution (Solid) | Laser Diffraction Method / Sieve Analysis | For powder raw materials, particle size distribution is measured using a laser diffraction instrument or controlled by standard sieve analysis, affecting solubility and formulation processes. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After digestion, AAS or ICP-MS is used to determine heavy metal contents such as lead, cadmium, mercury, and arsenic, complying with pharmacopoeial limits (e.g., ≤10 ppm). |
Technical Specifications of 4-Chloro-2-picoline
| Test Item | Specification |
|---|---|
| Appearance | Colorless to pale yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Refractive Index (n20/D) | 1.525–1.535 |
| Relative Density (20°C/25°C) | 1.100–1.120 g/cm³ |
| Odor | Characteristic pyridine-like odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Chloro-2-picoline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Chloro-2-picoline
Packaging of 4-Chloro-2-picoline
Industrial 4-Chloro-2-picoline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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