4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 3680-69-1 |
| Product name | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of antitumor drug intermediates | Introduces specific functional groups via substitution reactions |
| Agrochemicals | Preparation of pesticide active ingredients | Constructs target molecular structures through multistep reactions |
| Medical R&D | Used as probes for biological activity studies | Chemically modified for target validation |
| Materials Science | Development of functional ligand materials | Forms coordination complexes with metal ions |
Manufacturing Quality Control of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity Analysis | High-Performance Liquid Chromatography (HPLC) | Uses reversed-phase columns (e.g., C18) with UV detection (e.g., 254 nm) to quantify the main component and assess total impurities. The mobile phase is typically an acetonitrile-buffer salt system; quantification is performed using external standard or area normalization methods. |
| Related Substances / Impurity Analysis | HPLC or UPLC (Gradient Elution) | Employs high-resolution chromatographic systems with gradient elution to separate potential process impurities and degradation products. Mass spectrometry (LC-MS) is used for qualitative identification of unknown impurities, meeting ICH Q3A/B requirements. |
| Water Content | Karl Fischer Titration (KF) | Measures trace water content using either volumetric or coulometric methods, suitable for moisture-sensitive active pharmaceutical ingredients. Results are expressed as percentage (%). |
| Residual Solvents | Gas Chromatography (GC-FID/HS-GC) | Uses headspace injection or direct injection with FID detection to quantify residual organic solvents (e.g., methanol, ethyl acetate, DMF), following ICH Q3C guideline limits. |
| Drying Loss | Oven Drying Method | Dries samples at a specified temperature (e.g., 105°C) until constant weight is achieved, calculating the percentage loss to evaluate volatile components and adsorbed water content. |
| Melting Point Determination | Capillary Melting Point Apparatus | Determines the temperature range at which a compound transitions from solid to liquid state, serving as a physical constant for identification and preliminary purity assessment. |
| Structural Confirmation | Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), Infrared Spectroscopy (IR) | NMR (¹H/¹³C) confirms molecular framework and substitution positions; MS determines molecular weight and fragmentation patterns; IR verifies functional groups. Combined analysis ensures structural consistency. |
| Heavy Metal Residues | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | Performs detection of Pb, Cd, As, Hg, Cu, and other elemental residues according to Chinese Pharmacopoeia or USP General Chapters <232>/<233>, ensuring compliance with specified limits. |
| Specific Rotation (if chiral) | Measurement by Polarimeter | If the molecule contains chiral centers, specific rotation is measured to control optical purity. Measurements are made using sodium D-line (589 nm) at defined concentration and temperature conditions. |
| pH Value (in solution form) | pH Meter Measurement | Sample is dissolved in water at a specified concentration, and pH is measured to assess acid-base stability or compatibility with formulations. |
Technical Specifications of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
| Test Item | Specification |
|---|---|
| Appearance | White to orange to green crystalline powder |
| Purity | >=98.0% (LC-MS) |
| Melting Point | 182–186 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Safety Information of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Industrial 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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