Pyrrolo[2,3-d]pyrimidin-4-ol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 3680-71-5 |
| Product name | Pyrrolo[2,3-d]pyrimidin-4-ol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Pyrrolo[2,3-d]pyrimidin-4-ol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Pyrrolo[2,3-d]pyrimidin-4-ol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Pyrrolo[2,3-d]pyrimidin-4-ol
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Key intermediate for kinase inhibitor–based drugs, used in the synthesis of anticancer or anti-inflammatory candidate compounds | Multi-step organic synthesis, commonly involving cyclization, hydroxyl protection/deprotection, and coupling reactions |
| Medicinal Chemistry | Construction of purine analog scaffolds for designing biologically active molecules targeting the ATP-binding site | Synthesis route combining heterocyclic construction with functional group modification |
| Biochemical Research | Structural template for protein kinase inhibitors (e.g., JAK, EGFR), supporting structure–activity relationship (SAR) studies | Structural derivatization based on the pyrrolopyrimidine core, followed by biological activity screening |
Manufacturing Quality Control of Pyrrolo[2,3-d]pyrimidin-4-ol
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reverse-phase HPLC with UV detection at 260-280 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and detection of structurally similar impurities using gradient HPLC-UV; identification and quantification against qualified reference standards or threshold-based reporting. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common organic solvents (e.g., methanol, acetone, DMF) based on retention time and calibration curves. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Inductively coupled plasma mass spectrometry for simultaneous quantification of toxic elements (e.g., Pb, Cd, Hg, As) at sub-ppb levels after acid digestion. |
| Chloride Impurity | Ion Chromatography | Separation and conductivity detection of chloride ions in aqueous extract; quantified using external calibration with NaCl standard. |
| Sulfate Impurity | Ion Chromatography | Separation and conductivity detection of sulfate ions in aqueous extract; quantified using external calibration with Na2SO4 standard. |
| Residue on Ignition | Gravimetric Analysis | Ignition of sample at 700-800 C followed by weighing of non-volatile inorganic residue to assess inorganic ash content. |
| pH of Aqueous Suspension | pH Meter Measurement | Measurement of pH in a defined suspension (e.g., 1% w/v in water) using calibrated pH electrode to assess acidic/basic impurities. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating purity and identity consistency. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of foreign particles under controlled lighting against established reference standard. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using laser scattering to determine D10, D50, D90 values per ISO 13320. |
Technical Specifications of Pyrrolo[2,3-d]pyrimidin-4-ol
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 245-249°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Pyrrolo[2,3-d]pyrimidin-4-ol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Pyrrolo[2,3-d]pyrimidin-4-ol
Packaging of Pyrrolo[2,3-d]pyrimidin-4-ol
Industrial Pyrrolo[2,3-d]pyrimidin-4-ol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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