1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 373604-28-5 |
| Product name | 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 373604-28-5
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 373604-28-5 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 373604-28-5
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a synthetic intermediate in drug synthesis to construct fluorinated piperidine moieties in active pharmaceutical ingredients (e.g., kinase inhibitors, neuromodulators) | Deprotection under inert atmosphere catalyzed by base (e.g., TFA or HCl/dioxane) yields 3-fluoro-4-hydroxypiperidine carboxylic acid, followed by amidation or coupling reactions to introduce target pharmacophores |
| Fine Chemicals | Used as a chiral fluorinated building block in asymmetric synthesis and structural diversity screening | Undergoes Suzuki, Heck, and other cross-coupling reactions catalyzed by palladium or mediated by copper; alternatively serves as a nucleophile in alkylation/arylation modifications |
Manufacturing Quality Control of 373604-28-5
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main compound by UV absorption at specific wavelength using reverse-phase chromatography with calibrated standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient HPLC separation and UV detection. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., methanol, ethyl acetate) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration based on iodine-sulfur dioxide redox reaction. |
| Heavy Metals | ICP-MS | Quantifies trace metal impurities (e.g., Pb, Cd, Ni) by inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column and conductivity detection. |
| Optical Rotation | [a]D Measurement | Measures specific rotation at 589 nm to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using controlled heating and visual observation. |
| Residue on Ignition | Gravimetric Analysis | Quantifies inorganic ash content by high-temperature incineration followed by weighing of residual residue. |
| pH of Aqueous Solution | pH Meter | Measures hydrogen ion activity in a standardized aqueous suspension using calibrated glass electrode. |
| Particle Size Distribution | Laser Diffraction | Analyzes particle size distribution in suspension via light scattering pattern analysis. |
| Microbial Limits | Membrane Filtration | Detects aerobic microorganisms by filtration, membrane transfer to culture media, and colony enumeration. |
Technical Specifications of 373604-28-5
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | +15.0 to +19.0° (c=1, in methanol) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 373604-28-5
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 373604-28-5
Packaging of 373604-28-5
Industrial 373604-28-5 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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