5-Chloro-2-fluoro-3-methylpyridine Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 375368-84-6 |
| Product name | 5-Chloro-2-fluoro-3-methylpyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 5-Chloro-2-fluoro-3-methylpyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Chloro-2-fluoro-3-methylpyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Chloro-2-fluoro-3-methylpyridine
| Industry | Application | Process |
|---|---|---|
| Pesticides | Intermediate for insecticide synthesis | Used in Grignard reactions and substitution reactions |
| Pharmaceuticals | Intermediate for antitumor drug synthesis | Used in alkylation reactions and halogen exchange reactions |
| Chemicals | Intermediate for nitrogen-containing heterocyclic compound synthesis | Used in condensation reactions and cyclization reactions |
Manufacturing Quality Control of 5-Chloro-2-fluoro-3-methylpyridine
| Detection Item | Common Detection Method | Method Overview |
|---|---|---|
| Purity (Main Component Content) | HPLC (High-Performance Liquid Chromatography) | Using a C18 reverse-phase chromatographic column, with acetonitrile-water or methanol-water as the mobile phase (often with 0.1% formic acid or phosphoric acid to adjust pH), detected by a UV detector (wavelength 220–260 nm), quantified by external standard or internal standard methods, which can accurately determine the main component content and total impurities. |
| Impurity Profile Analysis | HPLC-UV / HPLC-MS | After separation by HPLC, impurities are identified and quantified using UV detection; when necessary, MS is coupled for structural identification to recognize synthetic intermediates, by-products, or degradation products (such as dechlorinated, defluorinated, or oxidized compounds). |
| Water Content | Karl Fischer Titration | The water content is determined by a quantitative reaction between water and an iodine-sulfur dioxide-pyridine-methanol system, with endpoint determination via electrochemical or visual methods, suitable for precise measurement of trace water (0.01%–1%), conforming to pharmacopoeia standards (e.g., USP/EP). |
| Residual Solvents | Gas Chromatography (GC) | Using DB-624 or HP-INNOWAX polar columns, headspace or direct injection, FID detector for measuring residual amounts of common organic solvents (e.g., methanol, acetonitrile, DMF, dichloromethane), conforming to ICH Q3C standards. |
| Chlorine and Fluorine Content | Coulometric Ion Chromatography (CIC) or ICP-OES | After combustion in an oxygen bomb or microwave digestion, the sample is converted into chloride and fluoride ions, which are analyzed by ion chromatography; alternatively, ICP-OES is used to measure total chlorine and fluorine content, ensuring compliance with process requirements. |
| Melting Point | Measurement by Melting Point Apparatus | The melting range (in °C) is measured using a digital melting point apparatus, serving as a physical constant for identification and purity assessment. Pure substances typically have a narrow melting range (e.g., 70–75°C, depending on literature or batch specifications). |
| Appearance and Color | Visual Inspection + Color Measurement | Observe solid color (should be white to light yellow crystals) and check for foreign matter; if necessary, use a colorimeter or color comparison method (e.g., APHA color) to quantify the yellow index, ensuring consistency in appearance across batches. |
| Heavy Metal Content | ICP-MS or Atomic Absorption Spectroscopy (AAS) | After wet digestion, heavy metals such as lead, cadmium, mercury, and arsenic are determined by ICP-MS or atomic absorption spectroscopy, complying with ICH Q3D or pharmacopoeia limits (e.g., ≤10 ppm). |
| Water Solubility/Dissolvability | Solubility Test | Determine solubility in different solvents (water, ethanol, ethyl acetate, DMSO, etc.), used for process optimization and formulation development reference. Typically, it is slightly soluble or insoluble in water but soluble in organic solvents. |
| Crystalline Form (if applicable) | X-ray Powder Diffraction (XRPD) | For solids that may exhibit polymorphism, XRPD is used to analyze crystalline structure, ensuring consistency in crystalline form between batches, avoiding effects on solubility, stability, or process performance (this item is optional if it is a solid API intermediate). |
Technical Specifications of 5-Chloro-2-fluoro-3-methylpyridine
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 42–46°C |
| Identification (NMR) | Conforms to reference standard |
| Identification (IR) | Conforms to reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 5-Chloro-2-fluoro-3-methylpyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Safety Information of 5-Chloro-2-fluoro-3-methylpyridine
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 5-Chloro-2-fluoro-3-methylpyridine
Industrial 5-Chloro-2-fluoro-3-methylpyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply