3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 376592-93-7 |
| Product name | 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Serves as a key structural scaffold for constructing biphenyl motifs in synthetic studies of sartan-class antihypertensive agents. |
| Organic Synthesis | Catalysis / Ligand Chemistry | Functions as a precursor for polydentate ligands or organocatalysts in asymmetric synthesis, leveraging its specific amino and hydroxyl functionality. |
| Research Reagents | Chemical Reagents | Used in laboratory-scale drug screening, design of novel molecular entities, and structure–activity relationship (SAR) studies. |
Manufacturing Quality Control of 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
| Detection Item | Common Analytical Methods | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Uses a C18 reversed-phase column with water-acetonitrile or methanol as the mobile phase (often adjusted pH with 0.1% formic acid or phosphoric acid). UV detection at 254–280 nm, quantified by external standard or internal standard method, to assess main component content and impurity peaks. |
| Impurity Profile (Related Substances) | HPLC-UV / HPLC-MS | Gradient elution HPLC separates degradation products and synthetic intermediates; mass spectrometry (MS) identifies unknown impurities such as deamination, oxidation, and esterification by-products, complying with ICH Q3B guidelines. |
| Water Content | Karl Fischer Titration | Quantitative reaction of iodine-sulfur dioxide-pyridine-methanol system with water, measured via coulometric or volumetric methods, to determine trace moisture in samples, ensuring compliance with pharmaceutical standards (typically ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Headspace or direct injection GC-FID/MS detects organic solvents potentially residual from synthesis, such as ethanol, ethyl acetate, DMF, dichloromethane, controlled according to ICH Q3C limits. |
| Heavy Metal Impurities | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, lead, cadmium, mercury, arsenic, copper, and other heavy metals are determined using AAS or inductively coupled plasma mass spectrometry (ICP-MS), meeting pharmacopeial limits (e.g., USP <232>, EP 2.5.10). |
| Melting Point | Melting Point Apparatus Measurement | Determined by capillary tube method or automated melting point instrument, used for preliminary identification and batch-to-batch consistency assessment (typical range ~200–230°C, requires actual calibration). |
| pH Value (Aqueous Solution) | pH Meter Measurement | Sample prepared as a solution at a defined concentration (e.g., 1 mg/mL), then pH measured using a calibrated pH meter, reflecting the amphoteric nature of carboxylic acid and amino groups (expected pH ≈ 4–6). |
| Chloride Ion / Sulfate Ion | Ion Chromatography (IC) | Used to detect inorganic anion impurities, such as residual hydrochloric or sulfuric acid from synthesis processes. Anion exchange column with conductivity detection enables quantitative analysis of Cl⁻, SO₄²⁻, etc. |
| Amino Group Content (Quantitative) | Titration (Acid-Base Titration or Ninhydrin Colorimetry) | Acid-base titration: Exploits amphoteric properties of carboxylic acid and amino groups, employing dual-endpoint titration for separate quantification; ninhydrin colorimetry: Amino groups react with ninhydrin to form a purple product, quantified by absorbance measurement at 570 nm. |
| Crystallinity and Polymorphism | X-Ray Powder Diffraction (XRPD) | Confirms solid-state form (polymorph) of the drug substance, preventing variations in solubility and stability due to different crystal forms—critical during formulation development. |
| UV-Visible Absorption Spectra | UV-Vis Spectrophotometer | Scans characteristic absorption peaks in the 200–400 nm range (e.g., π→π* and n→π* transitions of aromatic rings), used for qualitative identification and rapid concentration estimation (requires standard curve establishment). |
Technical Specifications of 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
| Test Item | Specification |
|---|---|
| Appearance | Light yellow to brown powder or crystals |
| Purity | >=98.5% (by LC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 245–249 °C |
| Identification (NMR) | Conforms to reference standard |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
Safety Information of 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
Industrial 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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