Ethyl (3S)-piperidine-3-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 37675-18-6 |
| Product name | Ethyl (3S)-piperidine-3-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Ethyl (3S)-piperidine-3-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Ethyl (3S)-piperidine-3-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Ethyl (3S)-piperidine-3-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Chiral intermediate for synthetic pharmaceuticals | Used in the synthesis of inhibitor-class drugs, such as a key chiral building block for dipeptidyl peptidase-4 (DPP-4) inhibitors (e.g., vildagliptin), where the piperidine ring is introduced via chiral pool synthesis or asymmetric synthesis. |
| Pharmaceutical Chemicals | Synthesis of peptides and peptidomimetics | Employed as a non-natural chiral amino acid derivative to construct peptide-based drug molecules with defined spatial conformation; its chiral center modulates biological activity and metabolic stability. |
| Agrochemicals | Chiral intermediate for agrochemicals | Applied in the synthesis of optically active insecticides or fungicides, leveraging chirality to enhance target-specific bioactivity while reducing environmental burden associated with diastereomeric impurities. |
| Research Reagents | Asymmetric catalysis research | Served as a chiral ligand or chiral precursor in asymmetric synthesis studies, supporting the development of novel chiral catalysts and synthetic routes for chiral pharmaceuticals. |
Manufacturing Quality Control of Ethyl (3S)-piperidine-3-carboxylate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Enantiomeric Excess (ee) | Chiral HPLC | Separation of (R)- and (S)-enantiomers on a chiral stationary phase, with quantification based on peak area ratio. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., ethanol, ethyl acetate) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to measure trace water via stoichiometric reaction. |
| Acid Value | Acid-Base Titration | Titration with standardized NaOH solution using phenolphthalein indicator to determine free carboxylic acid content. |
| Heavy Metals | ICP-OES | Multi-element quantification after acid digestion, based on atomic emission intensity at characteristic wavelengths. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue remaining after high-temperature ashing to assess inorganic impurities. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to confirm chiral integrity and concentration. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating purity and identity. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities using gradient reverse-phase HPLC with UV detection. |
| pH of Aqueous Solution | pH Meter | Measurement of pH in a defined aqueous suspension or solution to assess acidic/basic degradation products. |
Technical Specifications of Ethyl (3S)-piperidine-3-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Optical Rotation | +0.5 to +2.0 deg (c=1, in methanol) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Ethyl (3S)-piperidine-3-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Ethyl (3S)-piperidine-3-carboxylate
Safety Information of Ethyl (3S)-piperidine-3-carboxylate
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of Ethyl (3S)-piperidine-3-carboxylate
Industrial Ethyl (3S)-piperidine-3-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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