Methyl D-(-)-4-hydroxy-phenylglycinate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 37763-23-8 |
| Product name | Methyl D-(-)-4-hydroxy-phenylglycinate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl D-(-)-4-hydroxy-phenylglycinate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl D-(-)-4-hydroxy-phenylglycinate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl D-(-)-4-hydroxy-phenylglycinate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key chiral intermediate for synthesizing antibiotics (e.g., amoxicillin, cefadroxil, and other β-lactam antibiotics) | Produced via asymmetric synthesis or enzymatic resolution; used to construct the side-chain structure of antibiotic molecules |
| Pharmaceutical R&D | Building block for chiral drug synthesis | Employed as an optically pure intermediate in multistep organic synthesis to introduce side chains with defined stereochemistry |
| Fine Chemicals | Chiral auxiliary or ligand precursor | Derivatized for use in ligand synthesis for asymmetric catalytic reactions |
Manufacturing Quality Control of Methyl D-(-)-4-hydroxy-phenylglycinate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210-230 nm, comparing peak area to a certified reference standard. |
| Chiral Purity (Enantiomeric Excess) | Chiral HPLC | Separates enantiomers on a chiral stationary phase and calculates ee from peak area ratio of L- and D-forms. |
| Loss on Drying | Gravimetric (105 C, 2 h) | Measures mass loss after drying under controlled temperature and time to determine volatile content including moisture and solvents. |
| Residual Solvents | GC-FID | Quantifies residual methanol, ethyl acetate, or other process solvents by gas chromatography with flame ionization detection. |
| Heavy Metals | ICP-OES | Determines total heavy metal content (Pb, Cd, Hg, As, etc.) via inductively coupled plasma optical emission spectroscopy after acid digestion. |
| Chloride Impurity | Potentiometric Titration | Titrates chloride ions with silver nitrate using a silver indicator electrode to detect endpoint potential change. |
| Sulfate Impurity | Barium Sulfate Gravimetry | Precipitates sulfate as BaSO4 under acidic conditions and determines content by weighing the dried precipitate. |
| Specific Optical Rotation | Polarimetry | Measures rotation of plane-polarized light at 20 C using sodium D-line (589 nm) to confirm chiral integrity and concentration. |
| pH of Aqueous Solution | pH Meter | Measures hydrogen ion activity in a defined aqueous suspension or solution using calibrated glass electrode. |
| Particle Size Distribution | Laser Diffraction | Analyzes size distribution of solid particles in suspension by measuring angular variation in laser light scattering. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., hydrolysis products, diastereomers) using gradient HPLC with UV detection. |
| Microbial Contamination | Membrane Filtration | Tests for aerobic microorganisms by filtering sample through membrane, culturing on TSA, and enumerating colony-forming units. |
Technical Specifications of Methyl D-(-)-4-hydroxy-phenylglycinate
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 162–166°C |
| Optical Rotation | +15.0 to +17.0° (c=1, in AcOH) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl D-(-)-4-hydroxy-phenylglycinate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl D-(-)-4-hydroxy-phenylglycinate
Safety Information of Methyl D-(-)-4-hydroxy-phenylglycinate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Methyl D-(-)-4-hydroxy-phenylglycinate
Industrial Methyl D-(-)-4-hydroxy-phenylglycinate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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