1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 37813-30-2 |
| Product name | 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Manufacturing | Chiral intermediates for synthesizing antiviral agents (e.g., HIV protease inhibitors) and antibacterial drugs | Used as chiral auxiliaries or building blocks in multistep asymmetric synthesis; incorporated into the target molecular scaffold via deprotection, coupling, and related reactions |
| Pharmaceutical Manufacturing | Critical chiral building block for side-chain modification of β-lactam antibiotics | Applied in structural optimization of cephalosporins or penems through ester hydrolysis, amidation, cyclization, and related steps |
| Fine Chemicals | Precursor to chiral catalyst ligands | Derivatized to produce chiral phosphine ligands or N,O-bidentate ligands, employed in asymmetric hydrogenation, allylation, and related catalytic reactions |
Manufacturing Quality Control of 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210 nm based on peak area comparison against reference standard. |
| Chiral Purity | Chiral HPLC | Measures enantiomeric excess by separation on a chiral stationary phase and UV detection, comparing retention times and peak areas of (4R) and (4S) isomers. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., ethyl acetate, toluene, methanol) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine-based reagent where water reacts stoichiometrically with iodine and sulfur dioxide. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Fe) by inductively coupled plasma mass spectrometry after acid digestion and dilution. |
| Residual Palladium | ICP-MS | Specific quantification of palladium residues from catalytic hydrogenation steps using isotope-dilution ICP-MS for high sensitivity and accuracy. |
| Acid Value | Acid-Base Titration | Measures free carboxylic acid groups by titration with standardized NaOH solution using phenolphthalein or potentiometric endpoint detection. |
| Optical Rotation | [alpha]D Measurement | Determines specific optical rotation using a polarimeter at 20 C and sodium D-line (589 nm) to confirm chiral integrity and concentration. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., deprotected, hydrolyzed, or diastereomeric forms) using gradient HPLC with UV detection. |
| Residual Chloride | Ion Chromatography | Quantifies chloride ions from reagents or workup by separation on an anion-exchange column with suppressed conductivity detection. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus under controlled heating rate. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity of the sample against defined standards (e.g., white to off-white crystalline powder, free of visible particulates). |
Technical Specifications of 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.0% (by LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -69.0 to -67.0 deg (c=1, in CHCl3) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
Safety Information of 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
Industrial 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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